Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9908093 | 1.00 | KDM4E (0.43) | KDM4EPOLBGCKRIOK2RAB9A | |
| SCHEMBL9908089 | 0.91 | RAB9A (0.37) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9108208 | 0.91 | RAB9A (0.37) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9103283 | 0.89 | F2 (0.42) | KDM4EPOLBGCKRIOK2RAB9A | |
| SCHEMBL9908105 | 0.89 | RAB9A (0.43) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9108970 | 0.89 | RAB9A (0.43) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9103176 | 0.88 | GAA (0.38) | KDM4EPOLBGCKRAB9AGAA | |
| SCHEMBL9908112 | 0.88 | FFAR2 (0.46) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9106629 | 0.88 | FFAR2 (0.46) | KDM4EPOLBGCKRAB9ASMN1; SMN2 | |
| SCHEMBL9908099 | 0.88 | GAA (0.38) | KDM4EPOLBGCKRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | claimed |
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | KDM4E 4421/4885POLB 3911/4885GCK 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.