Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108166 | 0.92 | KMT2A (0.57) | KMT2ARAD52POLBKDM4EMEN1 | |
| SCHEMBL9109035 | 0.85 | ACHE (0.48) | KMT2ARAD52POLBPDE5AACHE | |
| SCHEMBL10468403 | 0.84 | TACR3 (0.53) | KMT2ARAD52POLBALDH1A1LMNA | |
| SCHEMBL9736104 | 0.81 | KMT2A (0.57) | KMT2ARAD52POLBKDM4EMEN1 | |
| SCHEMBL9108274 | 0.81 | KMT2A (0.57) | KMT2ARAD52POLBKDM4EMEN1 | |
| SCHEMBL9106781 | 0.80 | BCHE (0.50) | POLBBCHEACHEALDH1A1 | |
| SCHEMBL9108799 | 0.80 | ACHE (0.55) | KMT2ARAD52POLBKDM4EHTT | |
| SCHEMBL12043394 | 0.79 | BCHE (0.54) | KMT2ARAD52POLBHTTPDE5A | |
| SCHEMBL9108871 | 0.78 | KDM1A (0.57) | KMT2ARAD52POLBKDM4EMEN1 | |
| SCHEMBL9107725 | 0.78 | ACHE (0.58) | KMT2ARAD52POLBPDE5ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0278499-B1 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-09-28 | — | — | EP | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0278499-A2 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-17 | — | — | EP | disclosed |