Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108016 | 0.87 | ALDH1A1 (0.53) | ALDH1A1ACHEPDE5AMAPTTP53 | |
| SCHEMBL9108176 | 0.87 | TP53 (0.48) | ALDH1A1ACHEPDE5AMAPTTP53 | |
| SCHEMBL9108726 | 0.87 | NPSR1 (0.42) | ALDH1A1MAPTTP53KMT2AMEN1 | |
| SCHEMBL9108081 | 0.87 | CUL4A (0.47) | ALDH1A1ACHEMAPTTP53 | |
| SCHEMBL9107681 | 0.84 | MAPT (0.49) | ALDH1A1MAPTTP53KMT2AMEN1 | |
| SCHEMBL9107184 | 0.82 | CHRM5 (0.49) | — | |
| SCHEMBL9105979 | 0.81 | ALDH1A1 (0.44) | ALDH1A1ACHEPDE5AMAPTTP53 | |
| SCHEMBL9104273 | 0.81 | NPSR1 (0.43) | ALDH1A1MAPTTP53KMT2AMEN1 | |
| SCHEMBL9107616 | 0.77 | PARK7 (0.47) | ALDH1A1ACHEPDE5AMAPTTP53 | |
| SCHEMBL9108285 | 0.77 | GCK (0.46) | ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | ALDH1A1 646/4885ACHE 1278/4885PDE5A 2140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.