Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.35 |
| ▸ | USP19 | O94966 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107551 | 0.89 | RAB9A (0.36) | GCKUSP19HPGDSMN1; SMN2 | |
| SCHEMBL9107265 | 0.85 | GCK (0.40) | GCKUSP19 | |
| SCHEMBL9108616 | 0.83 | GCK (0.36) | GCKUSP19 | |
| SCHEMBL9103195 | 0.83 | DNMT1 (0.37) | GCKUSP19CCKBR | |
| SCHEMBL9108548 | 0.83 | GRN (0.39) | GCKUSP19 | |
| SCHEMBL9109372 | 0.81 | ALDH1A1 (0.44) | USP19MAPK1CCKBRHPGD | |
| SCHEMBL9105977 | 0.80 | HTR2A (0.36) | CCKBRHPGDSMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL9109667 | 0.78 | ALDH1A1 (0.43) | GCKUSP19SMN1; SMN2 | |
| SCHEMBL9109081 | 0.76 | ALDH1A1 (0.42) | GCK | |
| SCHEMBL9105621 | 0.76 | CUL4A (0.44) | USP19CASP3CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | GCK 488/4885USP19 3256/4885MAPK1 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.