Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.53 |
| ▸ | FEN1 | P39748 | 5/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7617752 | 0.85 | OPRM1 (0.43) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL9108107 | 0.83 | ALOX5AP (0.56) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL2280981 | 0.82 | ALOX5AP (0.54) | ALOX5APFEN1OPRM1OPRK1 | |
| SCHEMBL7176660 | 0.82 | FEN1 (0.55) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL7348499 | 0.79 | OPRM1 (0.43) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL7179227 | 0.79 | ALOX5AP (0.52) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL1458690 | 0.76 | CES2 (0.41) | OPRM1OPRK1F10ALDH1A1 | |
| SCHEMBL9396641 | 0.74 | CASP1 (0.48) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL28810677 | 0.74 | ALOX5AP (0.59) | ALOX5APFEN1 | |
| SCHEMBL10476295 | 0.74 | ALDH1A1 (0.63) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434261-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995003289-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |