Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.31 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9886431 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL9105543 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL428251 | 0.77 | TDP1 (0.41) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL10199255 | 0.73 | LMNA (0.42) | ALDH1A1TDP1MAPTL3MBTL1LMNA | |
| SCHEMBL3990674 | 0.72 | TDP1 (0.52) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL29595940 | 0.72 | TDP1 (0.52) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL19256724 | 0.71 | ALDH1A1 (0.32) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9886504 | 0.71 | ALDH1A1 (0.32) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL500039 | 0.70 | TDP1 (0.50) | ALDH1A1TDP1ATMHIF1AESPL1 | |
| SCHEMBL14247146 | 0.70 | MAPT (0.50) | ALDH1A1TDP1ATMHIF1AESPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108990-B2 | Cyclopropyl MIDA boronate | RIGEL PHARMACEUTICALS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20140296557-A1 | Cyclopropyl MIDA Boronate | MIDCAP FINANCIAL TRUST | 2014-10-02 | — | — | US | disclosed |
| US-8722916-B2 | Cyclopropyl MIDA boronate | RIGEL PHARMACEUTICALS, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20120142915-A1 | CYCLOPROPYL MIDA BORONATE | MIDCAP FINANCIAL TRUST | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296557-A1 | Cyclopropyl MIDA Boronate | MB, MMAB, MDK | ALDH1A1 1688/4885TDP1 2677/4885ATM 1802/4885 |
| US-20120142915-A1 | CYCLOPROPYL MIDA BORONATE | MB, MMAB, MDK | ALDH1A1 1688/4885TDP1 2677/4885ATM 1802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.