Sugi Predict

Sugi Predict / Compounds / SCHEMBL10199255

SCHEMBL10199255

SCHEMBL10199255

O=[N+]([O-])c1cc(-n2cnnn2)c([C@H]2C[C@@H]2C(F)(F)F)cc1F

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ HSP90AA1 P07900 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ NOTUM Q6P988 1/20 0.30
▸ KCNJ1 P48048 1/20 0.30
▸ KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433874 0.82 ALDH1A1 (0.43) LMNAALDH1A1MAPTHSP90AA1HTT
SCHEMBL10199133 0.80 NOTUM (0.33) ALDH1A1NOTUM
SCHEMBL19256724 0.76 ALDH1A1 (0.32) ALDH1A1MAPT
SCHEMBL9886504 0.76 ALDH1A1 (0.32) ALDH1A1MAPT
SCHEMBL9105543 0.73 ALDH1A1 (0.38) LMNAALDH1A1MAPTTDP1L3MBTL1
SCHEMBL9886431 0.73 ALDH1A1 (0.38) LMNAALDH1A1MAPTTDP1L3MBTL1
SCHEMBL9105540 0.73 ALDH1A1 (0.38) LMNAALDH1A1MAPTTDP1L3MBTL1
SCHEMBL429851 0.70 LMNA (0.42) LMNAALDH1A1MAPTHSP90AA1HTT
SCHEMBL22637131 0.70 LMNA (0.43) LMNAALDH1A1MAPTHSP90AA1HTT
SCHEMBL22637278 0.70 MAPT (0.48) LMNAALDH1A1MAPTHSP90AA1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9181222-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2015-11-10 — — US disclosed
US-9181222-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2015-11-10 — — US disclosed
US-20140329842-A1 Protein Kinase C Inhibitors and Uses Thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-11-06 — — US disclosed
US-20140329842-A1 Protein Kinase C Inhibitors and Uses Thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-11-06 — — US disclosed
US-8710223-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-04-29 — — US disclosed
US-8710223-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2014-04-29 — — US disclosed
US-20120022092-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF MIDCAP FINANCIAL TRUST 2012-01-26 — — US disclosed
US-20120022092-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF MIDCAP FINANCIAL TRUST 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140329842-A1 Protein Kinase C Inhibitors and Uses Thereof PRKCH, PRKCA, PRKCB LMNA 892/4885ALDH1A1 4361/4885MAPT 2530/4885
US-20120022092-A1 PROTEIN KINASE C INHIBITORS AND USES THEREOF PRKCH, PRKCA, PRKCB LMNA 892/4885ALDH1A1 4361/4885MAPT 2530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.