SCHEMBL9105724

SCHEMBL9105724

COC(=O)c1cnn(C)c1C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 2/20 0.48
CNR2 P34972 1/20 0.42
KMT2A Q03164 3/20 0.40
KDM4E B2RXH2 5/20 0.39
ALDH1A1 P00352 4/20 0.39
GAA P10253 2/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPC1 O15118 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.38
HSD17B10 Q99714 1/20 0.38
MEN1 O00255 1/20 0.38
CYP2C9 P11712 1/20 0.38
GLA P06280 1/20 0.38
SPR P35270 1/20 0.37
HTT P42858 1/20 0.37
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28965242 0.89 CYP1A2 (0.50) CYP1A2CYP2C19CNR2KMT2AKDM4E
SCHEMBL26117581 0.84 CYP1A2 (0.47) CYP1A2CYP2C19CNR2KMT2AKDM4E
SCHEMBL68535 0.83 PDE10A (0.41) KMT2AKDM4EALDH1A1L3MBTL1NPC1
SCHEMBL1458454 0.81 ALDH1A1 (0.49) CYP2C19KMT2AKDM4EALDH1A1TSHR
SCHEMBL19166978 0.79 ALDH1A1 (0.45) CYP1A2KMT2AKDM4EALDH1A1MAPK1
SCHEMBL9204354 0.79 CYP1A2 (0.44) CYP1A2CYP2C19KMT2AKDM4EALDH1A1
SCHEMBL10184712 0.78 KMT2A (0.53) CYP1A2CYP2C19KMT2AKDM4EALDH1A1
SCHEMBL9201765 0.78 CYP1A2 (0.43) CYP1A2CYP2C19CNR2KMT2AKDM4E
SCHEMBL1458362 0.78 RIPK2 (0.41) KMT2AKDM4EALDH1A1TSHRMEN1
SCHEMBL9196622 0.76 CYP1A2 (0.43) CYP1A2CYP2C19CNR2KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260076950-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME NOEMA PHARMA AG (CH) 2026-03-19 US disclosed
US-12544364-B2 Use of a phosphodiesterase 10 inhibitor for the treatment of tourette syndrome NOEMA PHARMA AG (CH) 2026-02-10 US disclosed
US-20250340563-A1 FUSED PYRIDAZINE DERIVATIVES AS NLRP3 INHIBITORS TAKEDA DEVELOPMENT CENTER AMERICAS, INC. 2025-11-06 US disclosed
EP-4504733-A1 FUSED PYRIDAZINE DERIVATIVES AS NLRP3 INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2025-02-12 EP disclosed
US-20240390339-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME NOEMA PHARMA AG (CH) 2024-11-28 US disclosed
US-11883385-B2 Use of a phosphodiesterase 10 inhibitor for the treatment of tourette syndrome NOEMA PHARMA AG (CH) 2024-01-30 US disclosed
EP-4284381-A1 METHODS FOR THE TREATMENT OF CHILDHOOD-ONSET FLUENCY DISORDER Noema Pharma AG (CH) 2023-12-06 EP disclosed
CN-117157077-A Methods of treating childhood onset fluency disorders 诺埃玛制药公司 2023-12-01 CN disclosed
US-20230381193-A1 METHODS FOR THE TREATMENT OF CHILDHOOD-ONSET FLUENCY DISORDER NOEMA PHARMA AG (CH) 2023-11-30 US disclosed
WO-2023194964-A1 FUSED PYRIDAZINE DERIVATIVES AS NLRP3 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-10-12 WO disclosed
CN-116137811-A Use of phosphodiesterase 10 inhibitors for the treatment of dolles syndrome 诺埃玛制药公司 2023-05-19 CN disclosed
US-20230149372-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME NOEMA PHARMA AG (CH) 2023-05-18 US disclosed
EP-4161526-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME Noema Pharma AG (CH) 2023-04-12 EP disclosed
WO-2022162193-A1 METHODS FOR THE TREATMENT OF CHILDHOOD-ONSET FLUENCY DISORDER NOEMA PHARMA AG (CH) 2022-08-04 WO disclosed
WO-2021245280-A9 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME NOEMA PHARMA AG (CH) 2022-01-27 WO disclosed
EP-2649070-B1 TRIAZOLOPYRIDINE COMPOUNDS HOFFMANN LA ROCHE (CH) 2014-09-17 EP disclosed
EP-2649070-A1 TRIAZOLOPYRIDINE COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2013-10-16 EP disclosed
US-8349824-B2 Triazolopyridine compounds HOFFMANN-LA ROCHE INC. (US) 2013-01-08 US disclosed
WO-2012076430-A1 TRIAZOLOPYRIDINE COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2012-06-14 WO disclosed
US-20120142665-A1 TRIAZOLOPYRIDINE COMPOUNDS HOFFMANN-LA ROCHE INC. 2012-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11883385-B2 Use of a phosphodiesterase 10 inhibitor for the treatment of tourette syndrome PDE2A, PDE3A, PDE5A CYP1A2 1074/4885CYP2C19 455/4885CNR2 2878/4885
US-20240390339-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME PDE2A, PDE3A, PDE5A CYP1A2 1074/4885CYP2C19 455/4885CNR2 2878/4885
US-20230149372-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME PDE2A, PDE3A, PDE5A CYP1A2 1074/4885CYP2C19 455/4885CNR2 2878/4885
US-12544364-B2 Use of a phosphodiesterase 10 inhibitor for the treatment of tourette syndrome PDE10A, PDE11A, PDE1A CYP1A2 703/4885CYP2C19 342/4885CNR2 2405/4885
US-20120142665-A1 TRIAZOLOPYRIDINE COMPOUNDS PDE5A, PDE3A, PDE3B CYP1A2 134/4885CYP2C19 87/4885CNR2 2568/4885
US-20230381193-A1 METHODS FOR THE TREATMENT OF CHILDHOOD-ONSET FLUENCY DISORDER PDE10A, PDE4A, PDE7B CYP1A2 959/4885CYP2C19 1607/4885CNR2 3129/4885
US-20250340563-A1 FUSED PYRIDAZINE DERIVATIVES AS NLRP3 INHIBITORS NLRP3, NLRP1, NOD1 CYP1A2 978/4885CYP2C19 1383/4885CNR2 3725/4885
US-20260076950-A1 USE OF A PHOSPHODIESTERASE 10 INHIBITOR FOR THE TREATMENT OF TOURETTE SYNDROME PDE10A, PDE11A, PDE3A CYP1A2 1056/4885CYP2C19 547/4885CNR2 1459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.