Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.58 |
| ▸ | BCHE | P06276 | 6/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107818 | 0.91 | ACHE (0.71) | ACHEBCHEGRIN1GRIN2AKDM4E | |
| SCHEMBL9107496 | 0.79 | ACHE (0.71) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL9109989 | 0.79 | KDM4E (0.39) | ACHEBCHEKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9107151 | 0.78 | ACHE (0.82) | ACHEBCHEKDM4ELMNASMN1; SMN2 | |
| SCHEMBL9107920 | 0.75 | ACHE (0.54) | ACHEKDM4ESMN1; SMN2POLBHTT | |
| SCHEMBL9584001 | 0.74 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL15491413 | 0.73 | KDM4E (0.41) | ACHEBCHEGRIN1GRIN2AKDM4E | |
| SCHEMBL9106878 | 0.73 | ACHE (0.84) | ACHEBCHE | |
| SCHEMBL9106869 | 0.72 | ACHE (0.54) | ACHEBCHEGRIN1GRIN2AKDM4E | |
| SCHEMBL9105519 | 0.71 | ACHE (0.47) | ACHEBCHEKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |