Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.82 |
| ▸ | BCHE | P06276 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106523 | 0.90 | ACHE (1.00) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| Hydrochloric Acid SCHEMBL10656143 | 0.89 | ACHE (0.97) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| SCHEMBL9171459 | 0.81 | ACHE (0.63) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| SCHEMBL9172816 | 0.81 | ACHE (0.63) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| SCHEMBL9106878 | 0.78 | ACHE (0.84) | ACHEBCHECHRM1 | |
| SCHEMBL9106864 | 0.78 | ACHE (0.58) | ACHEBCHEKDM4ESMN1; SMN2LMNA | |
| SCHEMBL9108559 | 0.77 | ACHE (0.59) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| SCHEMBL8781795 | 0.77 | ACHE (0.62) | ACHEBCHEALDH1A1KCNH2KDM4E | |
| SCHEMBL9106781 | 0.76 | BCHE (0.50) | ACHEBCHEALDH1A1HPGDHSD17B10 | |
| SCHEMBL9735758 | 0.76 | ACHE (0.57) | ACHEBCHEALDH1A1KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| JP-63203664-A | — | — | None | — | — | JP | disclosed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0278499-B1 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-09-28 | — | — | EP | disclosed |
| EP-0278499-B1 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-09-28 | — | — | EP | disclosed |
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0394950-A1 | Pyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-10-31 | — | — | EP | disclosed |
| EP-0278499-A3 | 9-AMINO-1,4-ETHANO-1,2,3,4-TETRAHYDROACRIDINE AND RELATED COMPOUNDS, INTERMEDIATES AND A PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | — | 1990-08-01 | — | — | EP | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |
| JP-S63203664-A | 9-AMINO-1,4-ETHANO-1,2,3,4-TETRAHYDROACRIDINE AND RELATED COMPOUNDS | HOECHST ROUSSEL PHARMA | 1988-08-23 | — | — | JP | disclosed |
| EP-0278499-A2 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0278499-A2 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-17 | — | — | EP | disclosed |