Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.84 |
| ▸ | BCHE | P06276 | 10/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107842 | 0.91 | ACHE (1.00) | ACHEBCHEEPHX2NOS1CHRM1 | |
| SCHEMBL9584001 | 0.79 | ACHE (1.00) | ACHEBCHEEPHX2NOS1 | |
| SCHEMBL9106869 | 0.78 | ACHE (0.54) | ACHEBCHENOS1CHRM1 | |
| SCHEMBL9107151 | 0.78 | ACHE (0.82) | ACHEBCHECHRM1 | |
| SCHEMBL9106918 | 0.74 | ACHE (0.55) | ACHE | |
| SCHEMBL9104297 | 0.74 | ACHE (0.71) | ACHEBCHE | |
| SCHEMBL9107496 | 0.74 | ACHE (0.71) | ACHEBCHEEPHX2NOS1 | |
| SCHEMBL10469455 | 0.73 | ACHE (0.52) | ACHEBCHEEPHX2NOS1 | |
| SCHEMBL9106864 | 0.73 | ACHE (0.58) | ACHEBCHE | |
| SCHEMBL22758298 | 0.71 | NR4A2 (0.50) | ACHEBCHEEPHX2NOS1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0278499-B1 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-09-28 | — | — | EP | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0278499-A2 | 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-17 | — | — | EP | disclosed |