Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105519 | 0.92 | ACHE (0.47) | KDM4EACHEKMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL9105256 | 0.84 | ACHE (0.54) | ACHEKDM1AALDH1A1 | |
| SCHEMBL9107920 | 0.84 | ACHE (0.54) | KDM4EACHEKMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL9106781 | 0.81 | BCHE (0.50) | ACHEBCHEL3MBTL1KDM1APOLB | |
| SCHEMBL9106864 | 0.79 | ACHE (0.58) | KDM4EACHESMN1; SMN2BCHELMNA | |
| SCHEMBL9355887 | 0.78 | NPC1 (0.46) | KDM4EACHEKMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL9106547 | 0.77 | ACHE (0.66) | ACHEKMT2ABCHEKDM1AALDH1A1 | |
| SCHEMBL9105577 | 0.77 | ACHE (0.52) | KDM4EACHEKMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL9105665 | 0.72 | ACHE (0.62) | ACHEBCHEKDM1A | |
| SCHEMBL10846908 | 0.72 | ACHE (0.51) | ACHEKMT2ANPSR1BCHEAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | claimed |
| US-5401749-A | Memory enhancers, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-03-28 | — | — | US | disclosed |
| US-4897400-A | ENHANCING MEMORY | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |