Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703281 | 0.86 | ALDH1A1 (0.55) | ALDH1A1AGTR1MEN1KMT2AHSD17B10 | |
| SCHEMBL8898794 | 0.83 | POLB (0.54) | POLBALDH1A1AGTR1MEN1KMT2A | |
| SCHEMBL3010654 | 0.82 | CA12 (0.49) | POLBALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL28138059 | 0.77 | L3MBTL1 (0.48) | ALDH1A1LMNAL3MBTL1CHRM5HSD17B10 | |
| SCHEMBL27703398 | 0.77 | ALDH1A1 (0.72) | POLBALDH1A1AGTR1MEN1KMT2A | |
| SCHEMBL3724574 | 0.75 | POLB (0.58) | POLBALDH1A1MEN1KMT2ACHRM5 | |
| SCHEMBL11959135 | 0.72 | ALDH1A1 (0.56) | POLBALDH1A1AGTR1 | |
| SCHEMBL30967408 | 0.72 | ALDH1A1 (0.61) | ALDH1A1CASP3CHRM5HSD17B10 | |
| SCHEMBL4730049 | 0.71 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4E | |
| SCHEMBL25412731 | 0.71 | KAT2B (0.46) | POLBALDH1A1KMT2ACASP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | POLB 3911/4885ALDH1A1 646/4885AGTR1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.