Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.70 |
| ▸ | NOS1 | P29475 | 4/20 | 0.70 |
| ▸ | NOS3 | P29474 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CCR6 | P51684 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16976334 | 0.85 | SYK (0.58) | NOS2NOS1NOS3MAPTCCR6 | |
| SCHEMBL23292322 | 0.84 | NOS2 (0.52) | NOS2NOS1NOS3MAP4K4MAPT | |
| SCHEMBL1460502 | 0.84 | CCR6 (0.54) | NOS2NOS1NOS3MAPTCCR6 | |
| SCHEMBL7821472 | 0.82 | NOS2 (1.00) | NOS2NOS1NOS3MAP4K4MAPT | |
| SCHEMBL5879617 | 0.82 | NOS2 (1.00) | NOS2NOS1NOS3MAP4K4MAPT | |
| SCHEMBL595392 | 0.81 | NOS2 (0.59) | NOS2NOS1NOS3MAP4K4MAPT | |
| SCHEMBL595393 | 0.81 | NOS2 (0.59) | NOS2NOS1NOS3MAP4K4MAPT | |
| SCHEMBL764570 | 0.81 | ALDH1A1 (0.65) | NOS2NOS1NOS3MAPTPOLB | |
| SCHEMBL4688313 | 0.80 | ALDH1A1 (0.53) | NOS2NOS1NOS3HSD17B10ALDH1A1 | |
| SCHEMBL28559024 | 0.79 | CCNK (0.60) | NOS2NOS1NOS3MAPTCCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476677-A1 | PROCESS FOR PRODUCTION OF 4-(5-METHYLPYRIDIN-2-YLAMINO)PIPERIDINE-1-CARBOXYLIC ACID DERIVATIVES | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-07-18 | — | — | EP | disclosed |
| US-20120142932-A1 | METHOD FOR MANUFACTURING 4-(5-METHYLPYRIDIN-2-YLAMINO)PIPERIDINE-1-CARBOXYLIC ACID DERIVATIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142932-A1 | METHOD FOR MANUFACTURING 4-(5-METHYLPYRIDIN-2-YLAMINO)PIPERIDINE-1-CARBOXYLIC ACID DERIVATIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-06-07 | — | — | US | disclosed |
| EP-1443046-B1 | NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME, PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME | KYORIN SEIYAKU KK (JP) | 2008-12-17 | — | — | EP | disclosed |
| US-20080194826-A1 | Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same | KYORIN PHARMACEUTICAL CO., LTD. | 2008-08-14 | — | — | US | disclosed |
| US-20080194826-A1 | Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same | KYORIN PHARMACEUTICAL CO., LTD. | 2008-08-14 | — | — | US | disclosed |
| US-7375115-B2 | 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-7375115-B2 | 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142932-A1 | METHOD FOR MANUFACTURING 4-(5-METHYLPYRIDIN-2-YLAMINO)PIPERIDINE-1-CARBOXYLIC ACID DERIVATIVE | PAH, ALK, ADSL | NOS2 3226/4885NOS1 3923/4885NOS3 4080/4885 |
| US-20080194826-A1 | Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same | CYP4F2, CYP1A2, CYP4B1 | NOS2 196/4885NOS1 590/4885NOS3 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.