Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 4/20 | 0.45 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21459349 | 0.88 | ALDH1A1 (0.50) | BCL2BCL2L2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31303303 | 0.88 | ALDH1A1 (0.50) | BCL2BCL2L2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21953166 | 0.84 | NOTUM (0.43) | NOTUMSMN1; SMN2MEN1KMT2ATAAR1 | |
| SCHEMBL9108017 | 0.84 | PDE5A (0.49) | NOTUMBCL2BCL2L2SMN1; SMN2MCL1 | |
| SCHEMBL9108805 | 0.83 | P2RX3 (0.43) | NOTUMBCL2BCL2L2SMN1; SMN2MCL1 | |
| SCHEMBL9105991 | 0.83 | SMN1; SMN2 (0.42) | NOTUMBCL2BCL2L2SMN1; SMN2MCL1 | |
| SCHEMBL9106358 | 0.83 | MCL1 (0.47) | BCL2BCL2L2SMN1; SMN2MCL1MME | |
| SCHEMBL4553514 | 0.81 | NOTUM (0.53) | NOTUMHPGDMEN1KMT2A | |
| SCHEMBL9103481 | 0.81 | NOTUM (0.40) | NOTUMSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL9103302 | 0.79 | SMN1; SMN2 (0.41) | NOTUMBCL2BCL2L2SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | NOTUM 65/4885BCL2 740/4885BCL2L2 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.