Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 4/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915239 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL911829 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL150785 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL1900817 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| Lithium Ion SCHEMBL562986 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL5967420 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL916916 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| Zinc Ion SCHEMBL915461 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL564168 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 | |
| SCHEMBL916091 | 0.97 | HMGCR (0.58) | HMGCRNR1I2KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003100-A1 | POLYESTER COMPOSITION AND POLYESTER MOLDED ARTICLE COMPRISING THE SAME | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20070065649-A1 | Polyester resin | TOYO BOSEKI KAUSHIKI KAISHA (JP) | 2007-03-22 | — | — | US | disclosed |