Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11783287 | 0.88 | L3MBTL1 (0.50) | CA2ATMKDM4ESTAT3ALDH1A1 | |
| SCHEMBL9165578 | 0.85 | CRHBP (0.46) | CA2ATMKDM4ESTAT3ALDH1A1 | |
| SCHEMBL11579051 | 0.83 | KMT2A (0.51) | CA2ATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28122001 | 0.83 | MAPT (0.50) | KDM4EALDH1A1TSHRSMN1; SMN2LMNA | |
| SCHEMBL910732 | 0.83 | CYP1A2 (0.62) | ALDH1A1CYP19A1CYP1A2CYP3A4TSHR | |
| SCHEMBL910751 | 0.83 | TAAR1 (0.64) | ALDH1A1CYP3A4TSHRLMNA | |
| SCHEMBL11703284 | 0.83 | ALDH1A1 (0.44) | CA2ATMKDM4ESTAT3ALDH1A1 | |
| SCHEMBL11491641 | 0.82 | CA2 (0.63) | CA2ATMKDM4ESTAT3ALDH1A1 | |
| SCHEMBL8067615 | 0.81 | PDE4B (0.56) | KDM4EALDH1A1CYP1A2CYP3A4BLM | |
| SCHEMBL910622 | 0.81 | STAT3 (0.60) | CA2ATMKDM4ESTAT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198295-B2 | Benzonaphthyridines | NYCOMED GMBH (DE) | 2012-06-12 | — | — | US | claimed |
| US-20090030029-A1 | Novel benzonaphthyridines | ALTANA PHARMA AG (DE) | 2009-01-29 | — | — | US | claimed |
| US-7470704-B2 | Benzonaphthyridines | NYCOMED GMBH (DE) | 2008-12-30 | — | — | US | claimed |
| EP-1537109-B1 | NOVEL BENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2007-04-18 | — | — | EP | claimed |
| US-20060167034-A1 | Novel benzonaphthyridines | ALTANA PHARMA AG (DE) | 2006-07-27 | — | — | US | claimed |
| EP-1537109-A1 | NOVEL BENZONAPHTHYRIDINES | ALTANA Pharma AG (DE) | 2005-06-08 | — | — | EP | claimed |
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2004022557-A1 | NOVEL BENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2004-03-18 | — | — | WO | claimed |
| US-6388081-B1 | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | LION BIOSCIENCE AG (DE) | 2002-05-14 | — | — | US | claimed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| EP-0977989-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2000-02-09 | — | — | EP | claimed |
| EP-0923734-A1 | QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES | Trega Biosciences, Inc. (US) | 1999-06-23 | — | — | EP | claimed |
| US-5840500-A | OPIOD RECEPTORS AS ANALGESICS AND CENTRALLY ACTING PAIN KILLERS | TREGA BIOSCIENCES, INC. (US) | 1998-11-24 | — | — | US | claimed |
| WO-1998034111-A1 | TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | claimed |
| WO-1998034115-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | claimed |
| WO-1998002741-A9 | QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES | — | 1998-05-22 | — | — | WO | claimed |
| WO-1998002741-A1 | QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-01-22 | — | — | WO | claimed |
| US-4661512-A | Adamantanamine derivatives, processes for their preparation and drugs in which they are present | S. A. PANMEDICA (FR) | 1987-04-28 | — | — | US | claimed |
| US-4010193-A | (ALKYLAMINO)ALKYL SUBSTITUTED BENZOATES, LOCAL ANESTHETIC, ANTIFIBRILLATORY, ANTIARRHYTHMIAL | CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1977-03-01 | — | — | US | claimed |
| US-3954774-A | HYPOTENSIVE AGENTS | MARION LABORATORIES, INC. (US) | 1976-05-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167034-A1 | Novel benzonaphthyridines | PDE4A, PDE3A, PDE3B | CA2 1934/4885ATM 2663/4885KDM4E 763/4885 |
| US-20090030029-A1 | Novel benzonaphthyridines | PDE4A, PDE3A, PDE3B | CA2 1934/4885ATM 2663/4885KDM4E 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.