Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5885410 | 0.90 | SIGMAR1 (0.40) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL7919904 | 0.85 | HCAR2 (0.43) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL30685308 | 0.83 | SIGMAR1 (0.38) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL28633081 | 0.81 | HCAR2 (0.39) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL11274144 | 0.79 | SIGMAR1 (0.42) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL11228399 | 0.78 | SIGMAR1 (0.44) | SIGMAR1DRD2HTR2ATRPM8ADRA1D | |
| SCHEMBL3433240 | 0.78 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL11220183 | 0.78 | HSD11B1 (0.46) | SIGMAR1DRD2HTR2ATRPM8ADRA1D | |
| SCHEMBL1246125 | 0.78 | SIGMAR1 (0.44) | SIGMAR1DRD2HTR2ATRPM8HCAR2 | |
| SCHEMBL30637538 | 0.78 | SIGMAR1 (0.44) | SIGMAR1DRD2HTR2ATRPM8HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1207038-A | Use of 3, 4-diphenyl chromans for producing a pharmaceutical composition for the prophylaxis or treatment of menopausal symptoms | NOVO NORDISK AS (DK) | 1999-02-03 | — | — | CN | disclosed |
| CN-1168101-A | Use of 3,4-diphenyl chromans for manufacture of pharmaceutical composition for treatment or prophylaxis of cerebral degenerative disorders | NOVO NORDISK AS (DK) | 1997-12-17 | — | — | CN | disclosed |
| CN-1168097-A | Use of 3,4-diphenyl chromans for manufacture of pharmaceutical composition for treatment or prophylaxis of idiopathic or physiologic gynaecomastia | NOVO NORDISK AS (DK) | 1997-12-17 | — | — | CN | disclosed |
| CN-1168098-A | Use of 3, 4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prevention of hyperlipoproteinemia, hypertriglyceridemia, hyperlipidemia or hypercholesterolemia or arteriosclerosis or for anticoagulant therapy | NOVO NORDISK AS (DK) | 1997-12-17 | — | — | CN | disclosed |
| CN-1168096-A | Use of 3,4-diphenyl chromans for mfg. pharmaceutical composition for treatment or prophylaxis of gynaecological disorders | NOVO NORDISK AS (DK) | 1997-12-17 | — | — | CN | disclosed |
| EP-0672412-A3 | Use of 3,4-diphenyl chromans for the manufacture of a medicament for lowering cholesterol levels. | LILLY CO ELI (US) | 1995-12-27 | — | — | EP | disclosed |
| EP-0672412-A2 | Use of 3,4-diphenyl chromans for the manufacture of a medicament for lowering cholesterol levels | ELI LILLY AND COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |