Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18957581 | 0.84 | MAOA (0.46) | ALDH1A1TSHRERN1TDP1MAOA | |
| SCHEMBL18957604 | 0.84 | CYP1A2 (0.42) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL1849155 | 0.80 | LMNA (0.67) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL28451899 | 0.79 | ALDH1A1 (0.69) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL2558631 | 0.79 | PARP10 (0.59) | LMNAKMT2AALDH1A1ERN1L3MBTL1 | |
| SCHEMBL6467176 | 0.79 | ALDH1A1 (0.47) | LMNAALDH1A1TSHRERN1TDP1 | |
| SCHEMBL23709919 | 0.79 | LMNA (0.50) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL14428178 | 0.79 | KMT2A (0.50) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL1134249 | 0.79 | LMNA (0.50) | LMNAGAAKMT2AALDH1A1TSHR | |
| SCHEMBL28439990 | 0.79 | TRIM24 (0.61) | LMNAGAAKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246317-B1 | BTK INHIBITOR | HUBEI BIO PHARMACEUTICAL INDUSTRIAL TECH INSTITUTE INC (CN) | 2023-02-22 | — | — | EP | disclosed |
| US-10662174-B2 | BTK inhibitor | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-05-26 | — | — | US | disclosed |
| US-10450292-B2 | Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols | Rutgers, The State University of New Jersesy (US) | 2019-10-22 | — | — | US | disclosed |
| CN-109890821-A | Amino-pyrrolopyrimidine ketone compound and its application method | 艾科尔公司 | 2019-06-14 | — | — | CN | disclosed |
| US-20190023682-A1 | INHIBITORS OF BACTERIAL RNA POLYMERASE: ARYLPROPANOYL, ARYLPROPENOYL, AND ARYLCYCLOPROPANECARBOXYL PHLOROGLUCINOLS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-01-24 | — | — | US | disclosed |
| EP-3246317-A1 | BTK INHIBITOR | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. (CN) | 2017-11-22 | — | — | EP | disclosed |
| US-20170313683-A1 | BTK INHIBITOR | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2017-11-02 | — | — | US | disclosed |
| US-20170313683-A1 | BTK INHIBITOR | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2017-11-02 | — | — | US | disclosed |
| WO-2017100645-A2 | INHIBITORS OF BACTERIAL RNA POLYMERASE: ARYLPROPANOYL, ARYLPROPENOYL, AND ARYLCYCLOPROPANECARBOXYL PHLOROGLUCINOLS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-06-15 | — | — | WO | disclosed |
| CN-105278268-A | Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge | FUJI XEROX CO LTD | 2016-01-27 | — | — | CN | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023682-A1 | INHIBITORS OF BACTERIAL RNA POLYMERASE: ARYLPROPANOYL, ARYLPROPENOYL, AND ARYLCYCLOPROPANECARBOXYL PHLOROGLUCINOLS | RNGTT, ELL, PGLS | LMNA 4180/4885GAA 373/4885KMT2A 917/4885 |
| US-10662174-B2 | BTK inhibitor | BTK, SYK, LYN | LMNA 4722/4885GAA 1783/4885KMT2A 1059/4885 |
| US-20170313683-A1 | BTK INHIBITOR | BTK, SYK, LYN | LMNA 4722/4885GAA 1783/4885KMT2A 1059/4885 |
| US-10450292-B2 | Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols | RNGTT, ELL, PGLS | LMNA 4180/4885GAA 373/4885KMT2A 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.