Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.75 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.47 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9116526 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3ACHE | |
| Maleic Acid SCHEMBL15239556 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3ACHE | |
| Fumaric Acid SCHEMBL365677 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3ACHE | |
| Fumaric Acid SCHEMBL365675 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3ACHE | |
| Maleic Acid SCHEMBL9296084 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3ACHE | |
| Fumaric Acid SCHEMBL1924598 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL15660586 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3ACHE | |
| Fumaric Acid SCHEMBL27654460 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL1924596 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL27634187 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130237551-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-12 | — | — | US | disclosed |
| CN-101605784-B | Aza-bridged-ring compound | ASTELLAS PHARMA INC JP | 2013-04-10 | — | — | CN | disclosed |
| CN-101605784-A | Aza-bridged-ring compound | ASTELLAS PHARMA INC (JP) | 2009-12-16 | — | — | CN | disclosed |
| CN-101243093-A | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |
| WO-1995011680-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237551-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | PFKP, PON1, FABP3 | MEN1 3344/4885KMT2A 4063/4885TSHR 2505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.