Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9116290 | 0.85 | F11 (0.44) | F11TTRPTPN1CA1CA2 | |
| SCHEMBL9476644 | 0.81 | TTR (0.38) | F11TTRPTPN1CA1CA2 | |
| SCHEMBL9117001 | 0.79 | HSP90AB1 (0.43) | F11PTPN1HSD17B10KDM4EGAA | |
| SCHEMBL9478488 | 0.78 | CYP1A2 (0.43) | TTRCA1CA2POLBBLM | |
| SCHEMBL2789591 | 0.75 | GAA (0.42) | F11CA2HSD17B10TSHRHIF1A | |
| SCHEMBL9235372 | 0.73 | CA2 (0.42) | F11PTPN1CA1CA2CA4 | |
| SCHEMBL6659568 | 0.72 | TTR (0.39) | F11TTRPTPN1CA1CA2 | |
| SCHEMBL5858355 | 0.71 | THRB (0.56) | TTRPTPN1CA2HSD17B10TSHR | |
| SCHEMBL28118607 | 0.71 | GAA (0.52) | PTPN1CA2HSD17B10TSHRHIF1A | |
| SCHEMBL29835994 | 0.70 | TTR (0.38) | TTRPTPN1HSD17B10TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995025712-A1 | HOMOGENTISIC ACID DERIVATIVES, METHODS OF TREATMENT OF DISEASE STATES MEDIATED BY PROTEIN KINASE C USING HOMOGENTISIC ACID DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-28 | — | — | WO | disclosed |