Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123641 | 0.90 | LMNA (0.48) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9690647 | 0.85 | LMNA (0.48) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9124267 | 0.82 | MAPT (0.50) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9692370 | 0.81 | ADRB2 (0.41) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9222642 | 0.80 | PTGES (0.47) | LMNAKMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL9123644 | 0.78 | LMNA (0.49) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9693018 | 0.76 | RAB9A (0.62) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9692116 | 0.74 | GAA (0.51) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9690566 | 0.73 | GAA (0.45) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9125655 | 0.73 | APEX1 (0.51) | LMNAPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | claimed |
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | disclosed |