Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 15/20 | 0.59 |
| ▸ | PPIF | P30405 | 2/20 | 0.45 |
| ▸ | FURIN | P09958 | 1/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125077 | 0.95 | PPIA (0.62) | PPIAPPIFC5AR1PLAU | |
| SCHEMBL2783284 | 0.92 | PPIA (0.58) | PPIAPPIF | |
| SCHEMBL9122341 | 0.90 | PPIA (0.51) | PPIAPPIFFURINC5AR1 | |
| SCHEMBL9124791 | 0.89 | NPC1 (0.51) | PPIAPPIFC5AR1MEN1NPC1 | |
| SCHEMBL9128504 | 0.88 | NPC1 (0.54) | PPIAC5AR1NPC1RAB9A | |
| SCHEMBL9124960 | 0.84 | PPIA (0.47) | PPIAPPIFMAPT | |
| SCHEMBL9126615 | 0.84 | PPIA (0.48) | PPIAPPIFCYP2D6KMT2A | |
| SCHEMBL9127376 | 0.84 | PPIA (0.53) | PPIAPPIFNPC1MAPTRAB9A | |
| SCHEMBL9127905 | 0.83 | PPIA (0.45) | PPIAPPIF | |
| SCHEMBL9126127 | 0.83 | PPIA (0.45) | PPIAPPIFMAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |