Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91346 | 0.93 | PPARA (0.38) | PPARGPPARDPPARAKDM4ELMNA | |
| SCHEMBL78412 | 0.88 | PPARG (0.39) | PPARGPPARDPPARAKDM4ELMNA | |
| SCHEMBL10289284 | 0.86 | PPARA (0.36) | PPARGPPARAKDM4ELMNACHRM5 | |
| SCHEMBL91348 | 0.84 | REN (0.50) | — | |
| SCHEMBL91298 | 0.82 | CHRM5 (0.37) | PPARASMN1; SMN2POLBCHRM5CHRM1 | |
| SCHEMBL78781 | 0.81 | KDM4E (0.36) | KDM4ELMNASMN1; SMN2TP53POLB | |
| SCHEMBL64456 | 0.81 | PPARG (0.39) | PPARGPPARDPPARAKDM4ELMNA | |
| SCHEMBL91275 | 0.80 | PPARG (0.38) | PPARGPPARDPPARAKDM4ELMNA | |
| SCHEMBL65813 | 0.79 | PPARG (0.40) | PPARGPPARDPPARAKDM4ETP53 | |
| SCHEMBL91347 | 0.78 | PPARG (0.38) | PPARGPPARDPPARAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |