Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78412 | 0.93 | PPARG (0.39) | KDM4ELMNATP53POLBSMN1; SMN2 | |
| SCHEMBL64196 | 0.93 | GHSR (0.36) | KDM4ELMNACHRM5CHRM1GHSR | |
| SCHEMBL65298 | 0.91 | CHRM5 (0.35) | TP53POLBCHRM5CHRM1ESR1 | |
| SCHEMBL66854 | 0.86 | CHRM2 (0.38) | KDM4ELMNATP53POLBSMN1; SMN2 | |
| SCHEMBL64456 | 0.86 | PPARG (0.39) | KDM4ELMNASMN1; SMN2CHRM5CHRM1 | |
| SCHEMBL64233 | 0.84 | CHRM5 (0.35) | KDM4ELMNATP53POLBSMN1; SMN2 | |
| SCHEMBL65813 | 0.84 | PPARG (0.40) | KDM4ETP53CHRM5CHRM1L3MBTL1 | |
| SCHEMBL78622 | 0.83 | SMN1; SMN2 (0.38) | POLBSMN1; SMN2CHRM5CHRM1CHRM2 | |
| SCHEMBL91270 | 0.81 | PPARG (0.38) | KDM4ELMNATP53POLBSMN1; SMN2 | |
| SCHEMBL78724 | 0.81 | KDM4E (0.34) | KDM4ELMNACHRM5CHRM1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |