Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78781 | 0.84 | KDM4E (0.36) | CHRM5CHRM1L3MBTL1TP53CHRM2 | |
| SCHEMBL64456 | 0.84 | PPARG (0.39) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL64034 | 0.80 | CHRM5 (0.38) | CHRM5CHRM1L3MBTL1MAPTNPC1 | |
| SCHEMBL91270 | 0.79 | PPARG (0.38) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL64056 | 0.76 | PPARG (0.38) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL64196 | 0.76 | GHSR (0.36) | PPARACHRM5CHRM1AOC3KDM4E | |
| SCHEMBL66854 | 0.75 | CHRM2 (0.38) | CHRM5CHRM1L3MBTL1TP53CHRM2 | |
| SCHEMBL65471 | 0.75 | REN (0.51) | REN | |
| SCHEMBL65814 | 0.75 | PPARG (0.39) | PPARGPPARDPPARAL3MBTL1MAPT | |
| SCHEMBL78854 | 0.73 | PPARG (0.40) | PPARGPPARDPPARAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |