Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78412 | 0.93 | PPARG (0.39) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL64196 | 0.93 | GHSR (0.36) | PPARACHRM5CHRM1AOC3PTGDR2 | |
| SCHEMBL91346 | 0.88 | PPARA (0.38) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL65471 | 0.86 | REN (0.51) | — | |
| SCHEMBL78781 | 0.86 | KDM4E (0.36) | CHRM5CHRM1PTGDR2KDM4ELMNA | |
| SCHEMBL65792 | 0.85 | PPARA (0.39) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL65813 | 0.84 | PPARG (0.40) | PPARGPPARDPPARACHRM5CHRM1 | |
| SCHEMBL78854 | 0.83 | PPARG (0.40) | PPARGPPARDPPARAPTGDR2KDM4E | |
| SCHEMBL78866 | 0.81 | PPARG (0.36) | PPARGPPARDPPARAKDM4ELMNA | |
| SCHEMBL91270 | 0.81 | PPARG (0.38) | PPARGPPARDPPARACHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |