SCHEMBL9130552

SCHEMBL9130552

CNc1nc(-c2ccc(-c3ccccc3)cc2)c(C(=O)OC)s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 6/20 0.55
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
LMNA P02545 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54
HTT P42858 1/20 0.54
RORC P51449 1/20 0.54
TRPM8 Q7Z2W7 1/20 0.51
GSTO1 P78417 1/20 0.51
ALDH1A1 P00352 3/20 0.50
ADORA1 P30542 2/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
KDM4E B2RXH2 1/20 0.50
ADORA3 P0DMS8 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid Methyl Ester SCHEMBL9132103 0.96 KMT2A (0.55) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL4395486 0.84 ADORA3 (0.61) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL28721843 0.84 DHODH (0.77) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL1919237 0.83 TRPM8 (0.54) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL974923 0.80 TRPM8 (0.73) MAPTSMN1; SMN2NPSR1RORCTRPM8
SCHEMBL276196 0.80 NTRK1 (0.57) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL28719395 0.79 SMN1; SMN2 (0.51) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL9360706 0.78 ALDH1A1 (0.48) KMT2AMEN1CYP1A2CYP2C9CYP2C19
SCHEMBL19669120 0.78 ALDH1A1 (0.72) DHODHKMT2AMEN1CYP1A2CYP2C9
SCHEMBL11278098 0.78 LMNA (0.64) DHODHKMT2AMEN1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5440040-A Drug for Aids therapy; viricides MEDIVIR AB (SE) 1995-08-08 US disclosed
US-5412100-A Fungicidal substituted acrylic esters BAYER AKTIENGESELLSCHAFT (DE) 1995-05-02 US disclosed
US-5254693-A Fungicidal substituted acrylic esters BAYER AKTIENGESELLSCHAFT (DE) 1993-10-19 US disclosed
US-5114959-A FUNGICIDAL SUBSTITUTED ACRYLIC ESTERS BAYER AKTIENGESELLSCHAFT (DE) 1992-05-19 US disclosed