SCHEMBL913096

SCHEMBL913096

c1ccc(C2CCC[Si](c3ccccc3)(c3ccccc3)O2)cc1

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9750709 0.98 TSHR (0.39) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL28596049 0.98 TSHR (0.39) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL2233573 0.79 TSHR (0.38) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL28894979 0.79 TSHR (0.38) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL211430 0.76 TSHR (0.42) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL2233588 0.76
SCHEMBL27507409 0.76
SCHEMBL2231431 0.76 TSHR (0.35) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL8427879 0.76 SLC6A2 (0.37) TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL28138890 0.75 TSHR (0.41) TSHRSLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110078927-B Heat-resistant boron-containing hydrogen-containing silicone oil and preparation method thereof 合肥工业大学 2021-04-20 CN claimed
US-20070203317-A1 HIGH REFRACTIVE INDEX FLEXIBLE SILICONE OPHTEC B.V. (NL) 2007-08-30 US claimed
US-7217778-B2 High refractive index flexible silicone OPHTEC B.V. (NL) 2007-05-15 US claimed
EP-1472305-A1 HIGH REFRACTIVE INDEX FLEXIBLE SILICONE Ophtec B.V. (NL) 2004-11-03 EP claimed
US-20030162929-A1 High refractive index flexible silicone OPHTEC B.V. (NL) 2003-08-28 US claimed
WO-2003066707-A1 HIGH REFRACTIVE INDEX FLEXIBLE SILICONE OPHTEC B.V. (NL) 2003-08-14 WO claimed
EP-1334991-A1 High refractive index flexible silicone Ophtec B.V. (NL) 2003-08-13 EP claimed
CN-117659715-A High-voltage-resistant silica gel heat-shrinkable tube and preparation method thereof 东莞市兴嘉电子科技有限公司 2024-03-08 CN disclosed
CN-115819773-A Preparation method of high-temperature-resistant benzyl silicone oil with narrow molecular weight distribution 浙江开化合成材料有限公司 2023-03-21 CN disclosed
CN-109300790-B Contact etch stop layer with sacrificial polysilicon layer 格芯(美国)集成电路科技有限公司 2021-11-02 CN disclosed
CN-110128461-B Radiation-resistant additive, synthesis thereof and method for preparing radiation-resistant silicon rubber material 北京航空材料研究院有限公司 2021-09-14 CN disclosed
CN-110016142-B Silicone oil containing pyrimidine boric acid structure and preparation method thereof 合肥工业大学 2021-08-03 CN disclosed
US-9393589-B2 Methods and materials for functional polyionic species and deposition thereof EASTMAN CHEMICAL COMPANY (US) 2016-07-19 US disclosed
US-4252932-A STORAGE STABILITY; BY-PRODUCT INHIBITION DOW CORNING CORPORATION (US) 1981-02-24 US disclosed
US-4239674-A ELASTOMERIC SEALANTS, ENCAPSULATING GELS, COATING RESINS DOW CORNING CORPORATION (US) 1980-12-16 US disclosed
US-4198131-A Silicone resin optical devices DOW CORNING CORPORATION (US) 1980-04-15 US disclosed
US-4147707-A MOLDING MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 1979-04-03 US disclosed
US-4077822-A Splice for use during the thermal stabilization of a flat multifilament band of an acrylic fibrous material comprising at least two segments CELANESE CORPORATION (US) 1978-03-07 US disclosed
US-3974122-A Heat-curable silicone resin compositions SHIN-ETSU CHEMICAL CO., LTD. (JA) 1976-08-10 US disclosed
US-3962160-A NOVEL ORGANOFUNCTIONAL (KETOXIMINO) SILANES AND ROOM TEMPERATURE, VULCANIZABLE COMPOSITIONS CONTAINING THE SAME GENERAL ELECTRIC COMPANY (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203317-A1 HIGH REFRACTIVE INDEX FLEXIBLE SILICONE MACF1, SMCHD1, RPIA TSHR 4289/4885SLC6A2 4126/4885SLC6A4 3853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.