SCHEMBL9134253

SCHEMBL9134253

CSC(=NCc1cnc(Cl)s1)NC#N

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
SMN1; SMN2 Q16637 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
KMT2A Q03164 2/20 0.34
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
MAPKAPK2 P49137 1/20 0.32
MEN1 O00255 1/20 0.32
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2971877 0.78 SMN1; SMN2 (0.42) ALDH1A1SMN1; SMN2
SCHEMBL7840106 0.76 RECQL (0.38) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL7764246 0.76 L3MBTL1 (0.34) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL7764248 0.76 L3MBTL1 (0.34) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL9134643 0.75 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2L3MBTL1GAAMAPKAPK2
SCHEMBL8518974 0.71 LMNA (0.36) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL8703241 0.69 L3MBTL1 (0.35) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL28357708 0.69 L3MBTL1 (0.33) ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA
SCHEMBL2971878 0.69 L3MBTL1 (0.31) L3MBTL1
SCHEMBL10725136 0.69 P2RX7 (0.49) ALDH1A1SMN1; SMN2LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5384324-A Insecticidally active cyano compounds NIHON BAYER AGROCHEM K.K. (JP) 1995-01-24 US claimed
EP-0364844-B1 Insecticidally active cyano compounds BAYER AGROCHEM KK (JP) 1994-03-16 EP claimed
EP-0364844-A1 Insecticidally active cyano compounds NIHON BAYER AGROCHEM K.K. (JP) 1990-04-25 EP claimed
JP-4029983-A None JP disclosed
US-5384324-A Insecticidally active cyano compounds NIHON BAYER AGROCHEM K.K. (JP) 1995-01-24 US disclosed
EP-0364844-B1 Insecticidally active cyano compounds BAYER AGROCHEM KK (JP) 1994-03-16 EP disclosed
JP-H0429983-A CYANOIMINO DERIVATIVE, ITS PREPARATION AND INSECTICIDE NIPPON SODA CO LTD 1992-01-31 JP disclosed
US-5066808-A PYRIDYL INSECTICIDALLY ACTIVE CYANO COMPOUNDS NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1991-11-19 US disclosed
EP-0364844-A1 Insecticidally active cyano compounds NIHON BAYER AGROCHEM K.K. (JP) 1990-04-25 EP disclosed