Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 5/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5862306 | 1.00 | ANPEP (0.46) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL9767573 | 0.95 | ANPEP (0.50) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL11029370 | 0.86 | ALDH1A1 (0.33) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL89565 | 0.82 | ANPEP (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL9767570 | 0.82 | ANPEP (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL9767580 | 0.82 | ANPEP (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL56538 | 0.80 | GMNN (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL56452 | 0.80 | GMNN (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL24073071 | 0.78 | ANPEP (0.41) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL29322854 | 0.78 | HSD17B10 (0.48) | ANPEPERAP1ERAP2TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132573-B2 | Amine derivative | NIPPON CHEMIPHER CO., LTD. (JP) | 2006-11-07 | — | — | US | claimed |
| US-20050288530-A1 | Amine derivative | NIPPON CHEMIPHAR CO., LTD (JP) | 2005-12-29 | — | — | US | claimed |
| EP-1538142-A1 | AMINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 2005-06-08 | — | — | EP | claimed |
| US-8163942-B2 | Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid | VELCURA THERAPEUTICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110003993-A1 | SALT OF (2S, 3S) -3- [ [ (1S) -1- ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMYL] OXIRANE-2-CARBOXYLIC ACID | NIPPON CHEMIPHAR CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-1619190-B1 | SALTS OF (2S,3S)-3- [[(1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL]CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID | NIPPON CHEMIPHAR CO (JP) | 2010-12-29 | — | — | EP | disclosed |
| EP-1619190-B1 | SALTS OF (2S,3S)-3- [[(1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL]CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID | NIPPON CHEMIPHAR CO (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-7795458-B2 | Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl] carbamoyl] oxirane-2-carboxylic acid | NIPPON CHEMIPHAR CO., LTD (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20090312563-A1 | SALT OF (2S, 3S)-3-[[ (1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID | NIPPON CHEMIPHAR CO., LTD. (JP) | 2009-12-17 | — | — | US | disclosed |
| US-7585988-B2 | Salt of (2S, 3S) -3- [[(1S) -1- isobutoxymethyl-3-methylbutyl] carbamoly] oxirane-2-carboxylic acid | NIPPON CHEMIPHAR CO., LTD. (JP) | 2009-09-08 | — | — | US | disclosed |
| CN-100349855-C | Amine derivative | NIPPON CHEMIPHAR CO (JP) | 2007-11-21 | — | — | CN | disclosed |
| US-7132573-B2 | Amine derivative | NIPPON CHEMIPHER CO., LTD. (JP) | 2006-11-07 | — | — | US | disclosed |
| EP-1538142-A4 | AMINE DERIVATIVE | NIPPON CHEMIPHAR CO (JP) | 2006-07-26 | — | — | EP | disclosed |
| EP-1619190-A1 | SALT OF (2S,3S)-3- (1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL CARBAMOYLOXIRANE-2-CARBOXYLIC ACID | NIPPON CHEMIPHAR CO., LTD. (JP) | 2006-01-25 | — | — | EP | disclosed |
| US-20050288530-A1 | Amine derivative | NIPPON CHEMIPHAR CO., LTD (JP) | 2005-12-29 | — | — | US | disclosed |
| US-20050288530-A1 | Amine derivative | NIPPON CHEMIPHAR CO., LTD (JP) | 2005-12-29 | — | — | US | disclosed |
| CN-1681769-A | Amine derivative | NIPPON CHEMIPHAR CO (JP) | 2005-10-12 | — | — | CN | disclosed |
| EP-1538142-A1 | AMINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
| EP-1538142-A1 | AMINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004024672-A1 | AMINE DERIVATIVE | NIPPON CHEMIPHAR CO.,LTD. (JP) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288530-A1 | Amine derivative | SRM, ARG1, ODC1 | ANPEP 734/4885ERAP1 1568/4885ERAP2 1956/4885 |
| US-20090312563-A1 | SALT OF (2S, 3S)-3-[[ (1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID | SLC7A1, CACNA1S, SLC7A5 | ANPEP 1363/4885ERAP1 2121/4885ERAP2 1775/4885 |
| US-20110003993-A1 | SALT OF (2S, 3S) -3- [ [ (1S) -1- ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMYL] OXIRANE-2-CARBOXYLIC ACID | SLC7A1, CACNA1S, SLC7A5 | ANPEP 1257/4885ERAP1 1784/4885ERAP2 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.