Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78478 | 0.84 | REN (0.41) | RENL3MBTL1POLBCNR1CNR2 | |
| SCHEMBL91360 | 0.82 | REN (0.44) | RENL3MBTL1CNR1CNR2LMNA | |
| SCHEMBL13131358 | 0.78 | REN (0.51) | RENL3MBTL1CNR1CNR2LMNA | |
| SCHEMBL78476 | 0.76 | ICMT (0.42) | CNR1CNR2LMNAHTTGSK3B | |
| SCHEMBL4602445 | 0.71 | ICMT (0.44) | RENCNR1CNR2MEN1KMT2A | |
| SCHEMBL13132335 | 0.71 | REN (0.49) | RENCNR1CNR2 | |
| SCHEMBL13131397 | 0.70 | REN (0.51) | RENCNR1CNR2 | |
| SCHEMBL78417 | 0.70 | CNR2 (0.53) | L3MBTL1CNR1CNR2LMNAHTT | |
| SCHEMBL13132155 | 0.69 | NPC1 (0.54) | L3MBTL1POLBLMNAHTTSMN1; SMN2 | |
| SCHEMBL91358 | 0.69 | HTR2A (0.51) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |