Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78865 | 0.90 | ICMT (0.42) | ICMTHTR6CNR1CNR2CHUK | |
| SCHEMBL4602445 | 0.82 | ICMT (0.44) | ICMTHTR6CNR1CNR2HRH2 | |
| SCHEMBL4602440 | 0.81 | ICMT (0.43) | ICMTHTR6CNR1CNR2HRH2 | |
| SCHEMBL78417 | 0.81 | CNR2 (0.53) | CNR1CNR2LMNAMAPK1HTT | |
| SCHEMBL91271 | 0.80 | ICMT (0.54) | ICMTHTR6CNR1CNR2HRH2 | |
| SCHEMBL13131421 | 0.79 | MAP3K14 (0.35) | ICMTCNR1CNR2CHUKLMNA | |
| SCHEMBL8247540 | 0.78 | ALDH1A1 (0.55) | ICMTCNR1CNR2HRH2LMNA | |
| SCHEMBL91362 | 0.76 | REN (0.43) | CNR1CNR2LMNAHTTGSK3B | |
| SCHEMBL4602810 | 0.74 | ICMT (0.44) | ICMTHTR6CNR1CNR2LMNA | |
| SCHEMBL22316061 | 0.74 | SCN9A (0.44) | ICMTHTR6CNR2GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |