SCHEMBL91415

SCHEMBL91415

Cc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 2/20 0.53
ACHE P22303 3/20 0.53
BCHE P06276 1/20 0.53
FFAR4 Q5NUL3 1/20 0.47
MAPT P10636 1/20 0.47
EPHX2 P34913 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
TP53 P04637 1/20 0.45
POLB P06746 2/20 0.44
NPBWR1 P48145 1/20 0.44
MCHR1 Q99705 1/20 0.44
KIF11 P52732 1/20 0.44
PDE2A O00408 1/20 0.44
GRIN2B Q13224 1/20 0.44
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
HCRTR2 O43614 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL2444176 0.97 GPR3 (0.52) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL1044896 0.93 KIF11 (0.53) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL13393735 0.93 TEAD4 (0.52) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL17110105 0.93 KIF11 (0.53) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL7729109 0.87 ACHE (0.45) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL9061558 0.87 RELA (0.59) GPR3ACHEBCHEGRIN2B
SCHEMBL9061480 0.87 BCHE (0.56) GPR3ACHEBCHEMAPTTP53
SCHEMBL17225200 0.87 ACACB (0.48) GPR3ACHEBCHEFFAR4MAPT
SCHEMBL9061561 0.87 RELA (0.59) GPR3ACHEBCHEGRIN2B
SCHEMBL9070626 0.87 MAPT (0.52) ACHEBCHEMAPTEPHX2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2650 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230131260-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2023-04-27 US claimed
US-11274083-B2 Substituted thiophenyl uracils, salts thereof and the use thereof as herbicidal agents SYNGENTA CROP PROTECTION AG (CH) 2022-03-15 US claimed
EP-3728235-B1 SUBSTITUTED THIOPHENYLURACILS , THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2022-02-09 EP claimed
EP-3728237-B1 SUBSTITUTED THIOPHENYLURACILS , THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2022-02-09 EP claimed
US-20210198267-A1 PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST BEONE MEDICINES I GMBH (CH) 2021-07-01 US claimed
US-20210087151-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS SYNGENTA CROP PROTECTION AG (CH) 2021-03-25 US claimed
EP-3321262-B1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2021-01-13 EP claimed
CN-112218860-A Substituted phenylthiouracils, their salts and their use as herbicides 先正达农作物保护股份公司 2021-01-12 CN claimed
CN-112154147-A Substituted phenylthiouracils, their salts and their use as herbicides 先正达农作物保护股份公司 2020-12-29 CN claimed
US-20200390100-A1 SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES BAYER AG (DE) 2020-12-17 US claimed
WO-2008008022-A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS ASTRAZENECA AB (SE) 2008-01-17 WO claimed
US-20080015237-A1 NEW COMPOUNDS I/418 ASTRAZENECA AB (SE) 2008-01-17 US claimed
WO-2007079214-A2 PROKINETICIN 2 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-12 WO claimed
WO-2007079163-A2 PROKINETICIN 1 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-12 WO claimed
US-20060142365-A1 Benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2006-06-29 US claimed
US-20040166137-A1 Hetero-substituted benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2004-08-26 US claimed
WO-2004043913-A2 HETERO-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS, INC. (US) 2004-05-27 WO claimed
US-20030119754-A1 Benzimidazole compounds and antiviral uses thereof TRIMERIS, INC. 2003-06-26 US claimed
WO-2002092575-A1 BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF TRIMERIS, INC. (US) 2002-11-21 WO claimed
US-6060453-A Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose GREENWICH PHARMACEUTICALS INCORPORATED (US) 2000-05-09 US claimed