Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073630 | 0.64 | HSP90AA1 (0.31) | — | |
| SCHEMBL7767430 | 0.62 | CDK2 (0.47) | ALDH1A1MAPTKMT2ACDK1CDK4 | |
| SCHEMBL13833302 | 0.61 | CDK1 (0.66) | ALDH1A1MAPTKMT2ACDK1CDK4 | |
| SCHEMBL7767421 | 0.61 | — | — | |
| SCHEMBL8864824 | 0.61 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1 | |
| SCHEMBL4160357 | 0.57 | CDK2 (0.52) | MAPTKMT2AATMCDK1CDK4 | |
| SCHEMBL10441417 | 0.54 | CDK2 (0.38) | MAPTKMT2ACDK1CDK4CDK2 | |
| SCHEMBL13802550 | 0.54 | CDK2 (0.40) | ALDH1A1MAPTKMT2AATMLMNA | |
| SCHEMBL5026853 | 0.54 | CDK2 (0.38) | MAPTKMT2ACDK1CDK4CDK2 | |
| SCHEMBL6402248 | 0.54 | CDK2 (0.40) | MAPTKMT2ACDK1CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586523-A4 | DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF | UNIV YALE (US) | 1995-11-29 | — | — | EP | disclosed |
| EP-0586523-A1 | DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF | YALE UNIVERSITY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5213972-A | Production of thymidine and deoxyuridine, intermediates for AZT | CHEMGEN CORPORATION (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1992020816-A1 | DETERMINATION OF PRODRUGS METABOLIZABLE BY THE LIVER AND THERAPEUTIC USE THEREOF | YALE UNIVERSITY (US) | 1992-11-26 | — | — | WO | disclosed |