Sugi Predict

Sugi Predict / Compounds / Fluoride

Fluoride

Fluoride

SCHEMBL915048

F.F.F.[S]c1ccccc1.[S]c1ccccc1.[S]c1ccccc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.40
▸ TDP1 Q9NUW8 5/20 0.35
▸ TSHR P16473 4/20 0.35
▸ CA1 P00915 2/20 0.35
▸ CA2 P00918 2/20 0.35
▸ CA9 Q16790 2/20 0.35
▸ ALOX12 P18054 2/20 0.35
▸ CA12 O43570 1/20 0.35
▸ GLA P06280 1/20 0.35
▸ CA3 P07451 1/20 0.35
▸ CA4 P22748 1/20 0.35
▸ CA14 Q9ULX7 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ CA7 P43166 1/20 0.35
▸ MAPT P10636 3/20 0.35
▸ HSD17B10 Q99714 3/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ PSMB8 P28062 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL943616 1.00 ALDH1A1 (0.40) ALDH1A1TDP1TSHRCA1CA2
Fluoride SCHEMBL915050 1.00 ALDH1A1 (0.40) ALDH1A1TDP1TSHRCA1CA2
Fluoride SCHEMBL943618 1.00 ALDH1A1 (0.40) ALDH1A1TDP1TSHRCA1CA2
Hydrochloric Acid SCHEMBL1847110 0.96 ALDH1A1 (0.38) ALDH1A1TDP1TSHRCA1CA2
Hydrochloric Acid SCHEMBL943271 0.96 ALDH1A1 (0.38) ALDH1A1TDP1TSHRCA1CA2
SCHEMBL2556 0.96 — —
Boric Acid SCHEMBL2460986 0.87 CA4 (0.43) ALDH1A1TDP1CA1CA2CA9
SCHEMBL997121 0.74 ALDH1A1 (0.60) ALDH1A1TDP1CA1CA2ALOX12
SCHEMBL149337 0.74 ALDH1A1 (0.60) ALDH1A1TDP1CA1CA2ALOX12
SCHEMBL10598460 0.71 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113773246-A Preparation method of 2-substituted-4-trifluoromethylpyridine 山东省农药科学研究院 2021-12-10 — — CN claimed
US-8203003-B2 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods UBE INDUSTRIES, LTD. (JP) 2012-06-19 — — US claimed
US-20110275833-A1 Novel 4-Fluoropyrrolidine-2-Carbonyl Fluoride Compounds and Their Preparative Methods UBE INDUSTRIES, LTD. (JP) 2011-11-10 — — US claimed
US-20100234605-A1 METHODS AND COMPOSITIONS FOR PRODUCING DIFLUOROMETHYLENE-AND TRIFLUOROMETHYL-CONTAINING COMPOUNDS IM&T RESEARCH, INC. (US) 2010-09-16 — — US claimed
WO-2010081014-A1 NOVEL 4-FLUOROPYRROLIDINE-2-CARBONYL FLUORIDE COMPOUNDS AND THEIR PREPARATIVE METHODS IM&T RESEARCH, INC. (US) 2010-07-15 — — WO claimed
US-20100174096-A1 Methods for Production of Optically Active Fluoropyrrolidine Derivatives IM&T RESEARCH, INC. (US) 2010-07-08 — — US claimed
WO-2009076345-A1 METHODS AND COMPOSITIONS FOR PRODUCING DIFLUOROMETHYLENE-AND TRIFLUOROMETHYL-CONTAINING COMPOUNDS IM & T RESEARCH, INC. (US) 2009-06-18 — — WO claimed
CN-113773246-B Preparation method of 2-substituted-4-trifluoromethylpyridine 山东省农药科学研究院 2023-03-31 — — CN disclosed
EP-3560910-B1 METHOD FOR MANUFACTURING DIFLUOROMETHYLENE COMPOUND DAIKIN IND LTD (JP) 2023-03-29 — — EP disclosed
EP-4097089-A1 TRIFLAZOLES AND METHODS OF MAKING THE SAME Trinapco, Inc (US) 2022-12-07 — — EP disclosed
US-11377407-B2 Method for producing difluoromethylene compound DAIKIN INDUSTRIES, LTD. (JP) 2022-07-05 — — US disclosed
US-11242322-B2 Triflazoles and methods of making the same TRINAPCO, INC. (US) 2022-02-08 — — US disclosed
CN-113773246-A Preparation method of 2-substituted-4-trifluoromethylpyridine 山东省农药科学研究院 2021-12-10 — — CN disclosed
US-4908198-A Preoxidizing carbon, fluorinating THE ELECTROSYNTHESIS COMPANY, INC. (US) 1990-03-13 — — US disclosed
EP-0304889-A2 Novel aristeromycin/adenosine derivatives MERRELL PHARMACEUTICALS INC. (US) 1989-03-01 — — EP disclosed
US-4196291-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1980-04-01 — — US disclosed
US-4141978-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1979-02-27 — — US disclosed
US-4113867-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1978-09-12 — — US disclosed
US-4001411-A ANTHELMINTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-01-04 — — US disclosed
US-3976691-A Dialkylaminosulfur trifluorides as fluorinating agents E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-08-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275833-A1 Novel 4-Fluoropyrrolidine-2-Carbonyl Fluoride Compounds and Their Preparative Methods PFAS, AFF4, PAICS ALDH1A1 916/4885TDP1 683/4885TSHR 2379/4885
US-20100174096-A1 Methods for Production of Optically Active Fluoropyrrolidine Derivatives QDPR, FDPS, DPYD ALDH1A1 600/4885TDP1 2743/4885TSHR 2800/4885
US-20100234605-A1 METHODS AND COMPOSITIONS FOR PRODUCING DIFLUOROMETHYLENE-AND TRIFLUOROMETHYL-CONTAINING COMPOUNDS FDPS, PFAS, FBL ALDH1A1 2855/4885TDP1 1576/4885TSHR 2090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.