Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9154882 | 0.99 | S1PR2 (0.42) | S1PR2S1PR1S1PR3LPAR2CYP1A2 | |
| Fosopamine SCHEMBL30567798 | 0.86 | MAPT (0.57) | S1PR2S1PR1S1PR3LPAR2CYP1A2 | |
| Fosopamine SCHEMBL828844 | 0.86 | MAPT (0.57) | S1PR2S1PR1S1PR3LPAR2CYP1A2 | |
| Fosopamine SCHEMBL9152610 | 0.84 | MAPT (0.58) | S1PR2S1PR1S1PR3LPAR2CYP1A2 | |
| SCHEMBL10600940 | 0.78 | ADRB2 (0.66) | CYP1A2TSHRNFKB1CYP3A4ADRB2 | |
| SCHEMBL9156756 | 0.78 | TSHR (0.61) | CYP1A2TSHRNFKB1CYP3A4ADRB2 | |
| SCHEMBL9159350 | 0.77 | CA1 (0.49) | CYP1A2TSHRNFKB1CYP3A4MAPT | |
| SCHEMBL9157336 | 0.77 | DRD2 (0.60) | TSHRNFKB1CYP3A4DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL9152256 | 0.77 | LMNA (0.62) | CYP1A2TSHRNFKB1CYP3A4ADRB2 | |
| Hydrochloric Acid SCHEMBL9715565 | 0.76 | DRD2 (0.58) | TSHRNFKB1CYP3A4DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430336-B1 | Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives | ZAMBON SPA (IT) | 1995-02-15 | — | — | EP | disclosed |
| US-5138084-A | PROCESS FOR THE PREPARATION OF 4-O-PHOSPHATES OF DOPAMINE AND DOPAMINE DERIVATIVES | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-08-11 | — | — | US | disclosed |
| EP-0430336-A2 | Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives | ZAMBON GROUP S.p.A. (IT) | 1991-06-05 | — | — | EP | disclosed |