Fosopamine

Fosopamine

SCHEMBL828844

CNCCc1ccc(OP(=O)(O)O)c(O)c1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.57
CYP1A2 P05177 2/20 0.57
TSHR P16473 2/20 0.57
NFKB1 P19838 2/20 0.57
HIF1A Q16665 2/20 0.57
HSD17B10 Q99714 2/20 0.57
TP53 P04637 1/20 0.57
ALOX15 P16050 1/20 0.57
MAPK1 P28482 1/20 0.57
THPO P40225 1/20 0.57
LMNA P02545 3/20 0.55
KDM4E B2RXH2 2/20 0.55
ALDH1A1 P00352 2/20 0.55
HPGD P15428 2/20 0.55
BLM P54132 2/20 0.55
GMNN O75496 1/20 0.55
GFER P55789 1/20 0.55
PMP22 Q01453 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fosopamine SCHEMBL30567798 1.00 MAPT (0.57) MAPTCYP1A2TSHRNFKB1HIF1A
Fosopamine SCHEMBL9152610 0.99 MAPT (0.58) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL9159471 0.88 MAPT (0.57) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL7363469 0.88 POLB (0.57) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL10604051 0.87 MAPT (0.53) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL9152005 0.86 S1PR2 (0.43) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL9151954 0.85 MAPT (0.50) MAPTCYP1A2TSHRNFKB1HIF1A
Hydrochloric Acid SCHEMBL9154882 0.85 S1PR2 (0.42) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL9156756 0.80 TSHR (0.61) MAPTCYP1A2TSHRNFKB1HIF1A
SCHEMBL9159350 0.80 CA1 (0.49) MAPTCYP1A2TSHRNFKB1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2961730-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XenoPort, Inc. (US) 2016-01-06 EP claimed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2014134005-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-09-04 WO claimed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 US claimed
CN-101486668-B Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT INC 2014-07-02 CN claimed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 US claimed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-7662987-B2 Oxidation of 1-acyl alkyl compound under anhydrous condition XENOPORT, INC. (US) 2010-02-16 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1485082-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF Xenoport, Inc. (US) 2004-12-15 EP claimed
WO-2003077902-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF XENOPORT, INC. (US) 2003-09-25 WO claimed
US-20030171303-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof ARBOR PHARMACEUTICALS, LLC 2003-09-11 US claimed
EP-0167204-B1 METHOD FOR IMPROVING THE ABSORPTION AND EFFECTIVENESS OF A CATECHOLAMINE COMPOUND SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) 1989-09-27 EP claimed
US-4673671-A CONVERSION TO MONO O-PHOSPHATE ESTER SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1987-06-16 US claimed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 EP disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 US disclosed
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2023-04-20 US disclosed
US-11607458-B2 Enrichment-triggered chemical delivery system GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2023-03-21 US disclosed
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels ASCENDIS PHARMA A/S (DE) 2023-01-24 US disclosed
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 EP disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
EP-3592393-B1 RELEASABLE CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2021-12-01 EP disclosed
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs ASCENDIS PHARMA A/S (DK) 2021-09-14 US disclosed
EP-3782649-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2021-02-24 EP disclosed
US-20210000965-A1 ENRICHMENT-TRIGGERED CHEMICAL DELIVERY SYSTEM GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC (US) 2021-01-07 US disclosed
EP-2459220-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2020-09-09 EP disclosed
US-10653795-B2 2020-05-19 US disclosed
EP-2741782-B1 PROTEIN CARRIER-LINKED PRODRUGS ASCENDIS PHARMA AS (DK) 2020-05-06 EP disclosed
CN-110545850-A Releasable conjugates QUIAPEG PHARMACEUTICALS AB 2019-12-06 CN disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
EP-2525831-B1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS ASCENDIS PHARMA AS (DK) 2019-05-15 EP disclosed
US-20180360974-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2018-12-20 US disclosed
WO-2018163131-A1 RELEASABLE CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2018-09-13 WO disclosed
US-9561285-B2 Carrier-linked carbamate prodrug linkers ASCENDIS PHARMA AS (DK) 2017-02-07 US disclosed
US-9533056-B2 Dipeptide-based prodrug linkers for aliphatic amine-containing drugs ASCENDIS PHARMA AS (DK) 2017-01-03 US disclosed
US-9353057-B2 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. (US) 2016-05-31 US disclosed
EP-2525830-B1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2016-05-11 EP disclosed
EP-2250143-B1 METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES XENOPORT INC (US) 2016-04-20 EP disclosed
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs ASCENDIS PHARMA A/S (DK) 2016-03-24 US disclosed
EP-2988783-A1 HYDROGEL-LINKED PRODRUGS RELEASING MODIFIED DRUGS Ascendis Pharma A/S (DK) 2016-03-02 EP disclosed
EP-2961730-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XenoPort, Inc. (US) 2016-01-06 EP disclosed
US-20150202317-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2015-07-23 US disclosed
US-9062094-B2 Dipeptide-based prodrug linkers for aliphatic amine-containing drugs ASCENDIS PHARMA AS (DK) 2015-06-23 US disclosed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20150087688-A1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA GMBH (DE) 2015-03-26 US disclosed
EP-2841109-A1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS Ascendis Pharma A/S (DK) 2015-03-04 EP disclosed
US-20140323402-A1 Protein Carrier-Linked Prodrugs Ascendis Phama A/S (DK) 2014-10-30 US disclosed
WO-2014173759-A1 HYDROGEL-LINKED PRODRUGS RELEASING MODIFIED DRUGS ASCENDIS PHARMA A/S (DK) 2014-10-30 WO disclosed
US-20140296257-A1 High-Loading Water-Soluable Carrier-Linked Prodrugs ASCENDIS PHARMA A/S (DK) 2014-10-02 US disclosed
WO-2014134005-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-09-04 WO disclosed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 US disclosed
US-20140243254-A1 Polymeric Hyperbranched Carrier-Linked Prodrugs ASCENDIS PHARMA A/S (DK) 2014-08-28 US disclosed
CN-101486668-B Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT INC 2014-07-02 CN disclosed
EP-2741779-A1 HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
EP-2741778-A1 POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
EP-2741782-A1 PROTEIN CARRIER-LINKED PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
CN-102573913-B Biodegradable polyethylene glycol-based water-insoluble hydrogels ASCENDIS PHARMA AS 2014-06-18 CN disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
EP-2717860-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI Pharma, LLC (US) 2014-04-16 EP disclosed
WO-2013160340-A1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA A/S (DK) 2013-10-31 WO disclosed
US-20130131355-A1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF XENOPORT, INC. (US) 2013-05-23 US disclosed
US-20130053301-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA A/S (DK) 2013-02-28 US disclosed
EP-1716115-B1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF XENOPORT INC (US) 2013-02-27 EP disclosed
WO-2013024048-A1 POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
WO-2013024047-A1 HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
WO-2013024049-A1 PROTEIN CARRIER-LINKED PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
US-8378137-B2 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. (US) 2013-02-19 US disclosed
US-20130035635-A1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS ASCENDIS PHARMA A/S (DK) 2013-02-07 US disclosed
WO-2012170676-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI PHARMA, LLC (US) 2012-12-13 WO disclosed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 US disclosed
CN-102573913-A Biodegradable polyethylene glycol-based water-insoluble hydrogels ASCENDIS PHARMA AS 2012-07-11 CN disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 US disclosed
EP-2459220-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2012-06-06 EP disclosed
US-8158152-B2 Preparing lyophilizates, especially those free of undesired extra components such as mono- or disaccharides; dosage forms of a wide variety of over 2000 drugs, such as rapidly dissolving tablets SCIDOSE LLC (US) 2012-04-17 US disclosed
US-8143437-B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XENOPORT, INC. (US) 2012-03-27 US disclosed
US-20120010425-A1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF XENOPORT, INC. (US) 2012-01-12 US disclosed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 US disclosed
EP-2371815-A1 Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XenoPort, Inc. (US) 2011-10-05 EP disclosed
US-8017776-B2 Methods for synthesis of acyloxyalkyl compounds XENOPORT, INC. (US) 2011-09-13 US disclosed
US-8003809-B2 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. (US) 2011-08-23 US disclosed
US-7989641-B2 Methods of synthesizing N-hydroxysuccinimidyl carbonates XENOPORT, INC. (US) 2011-08-02 US disclosed
WO-2011089214-A1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS ASCENDIS PHARMA AS (DK) 2011-07-28 WO disclosed
WO-2011089216-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2011-07-28 WO disclosed
US-7919454-B2 Methods of treating using conjugates transported by a PEPT2 transporter XENOPORT, INC. (US) 2011-04-05 US disclosed
US-7905852-B2 Skin-contacting-adhesive free dressing JENNINGS-SPRING BARBARA 2011-03-15 US disclosed
WO-2011012715-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2011-02-03 WO disclosed
EP-2250143-A2 METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES XenoPort, Inc. (US) 2010-11-17 EP disclosed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US disclosed
US-20100087667-A1 METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS XENOPORT, INC. (US) 2010-04-08 US disclosed
US-20100081830-A1 METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES XENOPORT, INC. (US) 2010-04-01 US disclosed
WO-2010024870-A1 SKIN-CONTACTING-ADHESIVE FREE DRESSING JENNINGS-SPRING BARBARA BROOKE (US) 2010-03-04 WO disclosed
US-20100041882-A1 METHODS FOR SYNTHESIS OF ACYLOXYALKYL COMPOUNDS XENOPORT, INC. (US) 2010-02-18 US disclosed
US-7662987-B2 Oxidation of 1-acyl alkyl compound under anhydrous condition XENOPORT, INC. (US) 2010-02-16 US disclosed
WO-2010017498-A1 METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES XENOPORT, INC. (US) 2010-02-11 WO disclosed
WO-2010017504-A1 METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS XENOPORT, INC. (US) 2010-02-11 WO disclosed
US-20090306036-A1 METHODS OF SCREENING AGENTS, CONJUGATES OR CONJUGATE MOIETIES FOR TRANSPORT BY A PEPT2 TRANSPORTER XENOPORT, INC. (US) 2009-12-10 US disclosed
US-20090239950-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF XENOPORT, INC. (US) 2009-09-24 US disclosed
US-20090216037-A1 Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof XENOPORT, INC. (US) 2009-08-27 US disclosed
WO-2009094569-A2 METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES XENOPORT, INC. (US) 2009-07-30 WO disclosed
US-20090192325-A1 ENANTIOMERICALLY RESOLVING ACYLOXYALKYL THIOCARBONATES USED IN SYNTHESIZING ACYLOXYALKYL CARBAMATE PRODRUGS XENOPORT, INC. (US) 2009-07-30 US disclosed
US-7560483-B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XENOPORT, INC. (US) 2009-07-14 US disclosed
US-7511158-B2 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. (US) 2009-03-31 US disclosed
US-7507546-B2 Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter XENOPORT, INC. (US) 2009-03-24 US disclosed
US-20090005722-A1 Skin-contacting-adhesive free dressing JENNLNGS-SPRING BARBARA 2009-01-01 US disclosed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP disclosed
US-20070244331-A1 Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof XENOPORT, INC. 2007-10-18 US disclosed
US-7227028-B2 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. (US) 2007-06-05 US disclosed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO disclosed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US disclosed
US-20070037988-A9 Formation of a thiocarbamate from a haloformic compound, dehalo-esterification, coupling an N-hydroxysuccinimide or secondary amide-containing drug; prodrugs of gabapentin and baclofen; improved bioavailability XENOPORT, INC. 2007-02-15 US disclosed
EP-1716115-A2 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF Xenoport, Inc. (US) 2006-11-02 EP disclosed
EP-1406493-A4 ADMINISTRATION OF AGENTS VIA THE PEPT-2 TRANSPORTER XENOPORT INC (US) 2006-06-14 EP disclosed
US-20050239725-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XENOPORT, INC. 2005-10-27 US disclosed
US-6955888-B2 Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter XENOPORT (US) 2005-10-18 US disclosed
US-20050222431-A1 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT, INC. 2005-10-06 US disclosed
US-20050214853-A1 Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter XENOPORT, INC. (US) 2005-09-29 US disclosed
EP-1575494-A2 ENGINEERING ABSORPTION OF THERAPEUTIC COMPOUNDS VIA COLONIC TRANSPORTERS Xenoport, Inc. (US) 2005-09-21 EP disclosed
US-6927036-B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XERO PORT, INC. (US) 2005-08-09 US disclosed
WO-2005070961-A1 HUMAN ORGANIC SOLUTE TRANSPORTERS XENOPORT, INC. (US) 2005-08-04 WO disclosed
WO-2005066122-A2 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF XENOPORT, INC. (US) 2005-07-21 WO disclosed
US-20050070715-A1 Methods for synthesis of acyloxyalkyl compounds ARBOR PHARMACEUTICALS, LLC 2005-03-31 US disclosed
WO-2005010011-A2 METHODS OF SYNTHESIS OF ACYLOXYALKYL COMPOUNDS XENOPORT, INC. (US) 2005-02-03 WO disclosed
EP-1485082-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF Xenoport, Inc. (US) 2004-12-15 EP disclosed
US-20040161424-A1 Human organic solute transporters XENOPORT 2004-08-19 US disclosed
WO-2004033655-A2 HUMAN ORGANIC SOLUTE TRANSPORTERS XENOPORT, INC. (US) 2004-04-22 WO disclosed
EP-1406493-A1 ADMINISTRATION OF AGENTS VIA THE PEPT-2 TRANSPORTER Xenoport, Inc. (US) 2004-04-14 EP disclosed
WO-2003077902-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF XENOPORT, INC. (US) 2003-09-25 WO disclosed
US-20030171303-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof ARBOR PHARMACEUTICALS, LLC 2003-09-11 US disclosed
US-20030158254-A1 Engineering absorption of therapeutic compounds via colonic transporters XENOPORT, INC. 2003-08-21 US disclosed
WO-2003065982-A2 ENGINEERING ABSORPTION OF THERAPEUTIC COMPOUNDS VIA COLONIC TRANSPORTERS XENOPORT, INC. (US) 2003-08-14 WO disclosed
US-20030017964-A1 Administration of agents via the PEPT-2 transporter XENOPORT, INC. 2003-01-23 US disclosed
WO-2002100172-A1 ADMINISTRATION OF AGENTS VIA THE PEPT-2 TRANSPORTER XENOPORT, INC. (US) 2002-12-19 WO disclosed
EP-0607394-B1 DIPHOSPHATES OF CATECHOLAMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ZAMBON SPA (IT) 1998-09-16 EP disclosed
US-5438047-A Diphosphates of catecholamines and pharmaceutical compositions containing them ZAMBON GROUP S.P.A. (IT) 1995-08-01 US disclosed
EP-0430336-B1 Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives ZAMBON SPA (IT) 1995-02-15 EP disclosed
EP-0607394-A1 DIPHOSPHATES OF CATECHOLAMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ZAMBON GROUP S.p.A. (IT) 1994-07-27 EP disclosed
WO-1994003461-A1 DIPHOSPHATES OF CATECHOLAMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ZAMBON GROUP S.P.A. (IT) 1994-02-17 WO disclosed
US-5138084-A PROCESS FOR THE PREPARATION OF 4-O-PHOSPHATES OF DOPAMINE AND DOPAMINE DERIVATIVES SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1992-08-11 US disclosed
EP-0430336-A2 Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives ZAMBON GROUP S.p.A. (IT) 1991-06-05 EP disclosed
EP-0167204-B1 METHOD FOR IMPROVING THE ABSORPTION AND EFFECTIVENESS OF A CATECHOLAMINE COMPOUND SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) 1989-09-27 EP disclosed
US-4673671-A CONVERSION TO MONO O-PHOSPHATE ESTER SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1987-06-16 US disclosed
US-4673671-A CONVERSION TO MONO O-PHOSPHATE ESTER SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1987-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (38 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296257-A1 High-Loading Water-Soluable Carrier-Linked Prodrugs ABCB11, SLCO1B1, SLC7A1 MAPT 1533/4885CYP1A2 240/4885TSHR 4063/4885
US-20100087667-A1 METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS CPS1, ASNS, NAAA MAPT 4368/4885CYP1A2 251/4885TSHR 2124/4885
US-20150202317-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS DNPEP, PEPD, DAO MAPT 1232/4885CYP1A2 3096/4885TSHR 3880/4885
US-20130035635-A1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS CTSL, SLC16A7, SLC16A8 MAPT 1371/4885CYP1A2 1948/4885TSHR 2746/4885
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 MAPT 1671/4885CYP1A2 1645/4885TSHR 3360/4885
US-20100081830-A1 METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES CPS1, SI, ASNS MAPT 4426/4885CYP1A2 1067/4885TSHR 4038/4885
US-20050070715-A1 Methods for synthesis of acyloxyalkyl compounds AADAC, CYP2D6, CYP3A7 MAPT 4121/4885CYP1A2 19/4885TSHR 3334/4885
US-20090239950-A1 METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF AADAC, UGT1A1, ABHD5 MAPT 4464/4885CYP1A2 21/4885TSHR 4384/4885
US-20180360974-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 MAPT 3354/4885CYP1A2 185/4885TSHR 1783/4885
US-20130053301-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS DNPEP, PEPD, DAO MAPT 1232/4885CYP1A2 3096/4885TSHR 3880/4885
US-20050214853-A1 Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter SLC47A2, SLC10A2, SLC2A2 MAPT 1005/4885CYP1A2 1744/4885TSHR 1761/4885
US-20050222431-A1 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof CPS1, ACMSD, NAAA MAPT 3811/4885CYP1A2 262/4885TSHR 3390/4885
US-11607458-B2 Enrichment-triggered chemical delivery system HMGB1, PAICS, CCL2 MAPT 1806/4885CYP1A2 1176/4885TSHR 4493/4885
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA MAPT 3200/4885CYP1A2 311/4885TSHR 2534/4885
US-20090306036-A1 METHODS OF SCREENING AGENTS, CONJUGATES OR CONJUGATE MOIETIES FOR TRANSPORT BY A PEPT2 TRANSPORTER SLC47A2, SLC10A2, SLC2A2 MAPT 1005/4885CYP1A2 1744/4885TSHR 1761/4885
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 MAPT 1671/4885CYP1A2 1645/4885TSHR 3360/4885
US-20090216037-A1 Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof CPS1, ACMSD, NAAA MAPT 3811/4885CYP1A2 262/4885TSHR 3390/4885
US-20140243254-A1 Polymeric Hyperbranched Carrier-Linked Prodrugs P4HA1, CYP8B1, PAH MAPT 905/4885CYP1A2 137/4885TSHR 3949/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 MAPT 3354/4885CYP1A2 185/4885TSHR 1783/4885
US-10653795-B2 PTMS, MSN, CD44 MAPT 2992/4885CYP1A2 496/4885TSHR 898/4885
US-20030158254-A1 Engineering absorption of therapeutic compounds via colonic transporters SLC5A6, SLC16A3, SLC16A1 MAPT 1655/4885CYP1A2 1066/4885TSHR 3686/4885
US-20090192325-A1 ENANTIOMERICALLY RESOLVING ACYLOXYALKYL THIOCARBONATES USED IN SYNTHESIZING ACYLOXYALKYL CARBAMATE PRODRUGS AADAC, NAAA, APEH MAPT 4849/4885CYP1A2 325/4885TSHR 1849/4885
US-20130131355-A1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF CPS1, ACMSD, NAAA MAPT 3811/4885CYP1A2 262/4885TSHR 3390/4885
US-20140323402-A1 Protein Carrier-Linked Prodrugs SLC6A7, PRAP1, PELP1 MAPT 574/4885CYP1A2 2939/4885TSHR 3425/4885
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA MAPT 3200/4885CYP1A2 311/4885TSHR 2534/4885
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels PLG, PHYKPL, PLOD3 MAPT 1671/4885CYP1A2 1645/4885TSHR 3360/4885
US-20070244331-A1 Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof CPS1, ACMSD, NAAA MAPT 3811/4885CYP1A2 262/4885TSHR 3390/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 MAPT 3354/4885CYP1A2 185/4885TSHR 1783/4885
US-20030017964-A1 Administration of agents via the PEPT-2 transporter SLC10A2, SLC10A1, SLC47A2 MAPT 660/4885CYP1A2 2658/4885TSHR 1177/4885
US-20100041882-A1 METHODS FOR SYNTHESIS OF ACYLOXYALKYL COMPOUNDS AADAC, CYP2D6, CYP3A7 MAPT 4121/4885CYP1A2 19/4885TSHR 3334/4885
US-20120010425-A1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF CPS1, ACMSD, NAAA MAPT 3811/4885CYP1A2 262/4885TSHR 3390/4885
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs PTMS, PGLS, PAM MAPT 1984/4885CYP1A2 339/4885TSHR 1252/4885
US-20210000965-A1 ENRICHMENT-TRIGGERED CHEMICAL DELIVERY SYSTEM HMGB1, PAICS, CCL2 MAPT 1806/4885CYP1A2 1176/4885TSHR 4493/4885
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs PTMS, PGLS, PAM MAPT 1984/4885CYP1A2 339/4885TSHR 1252/4885
US-20070037988-A9 Formation of a thiocarbamate from a haloformic compound, dehalo-esterification, coupling an N-hydroxysuccinimide or secondary amide-containing drug; prodrugs of gabapentin and baclofen; improved bioavailability SLC6A13, SLC6A11, SLC6A1 MAPT 1378/4885CYP1A2 385/4885TSHR 928/4885
US-20030171303-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof AADAC, UGT1A1, AGPAT5 MAPT 4481/4885CYP1A2 24/4885TSHR 4306/4885
US-20050239725-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof AADAC, UGT1A1, ABHD5 MAPT 4464/4885CYP1A2 21/4885TSHR 4384/4885
US-20150087688-A1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ABCB1, CYP2D6, LDHA MAPT 4542/4885CYP1A2 110/4885TSHR 2196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.