Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766637 | 0.90 | RAB9A (0.52) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL9154059 | 0.87 | LMNA (0.50) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL9158938 | 0.87 | RAB9A (0.50) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL9155401 | 0.84 | RAB9A (0.49) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL9157673 | 0.82 | ALDH1A1 (0.46) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL9159976 | 0.82 | MAPT (0.49) | RAB9AMAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL30017394 | 0.81 | NQO1 (0.54) | NQO1DGAT1 | |
| SCHEMBL1390547 | 0.81 | NQO1 (0.54) | NQO1DGAT1 | |
| SCHEMBL9875386 | 0.81 | RAB9A (0.53) | RAB9AMAPTL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL28616323 | 0.81 | NQO1 (0.74) | NQO1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5205962-A | Stable liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |