SCHEMBL9155405

SCHEMBL9155405

O=C1C=CC(=O)N1c1cc(Cl)ccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 6/20 0.59
ALDH1A1 P00352 4/20 0.49
NPSR1 Q6W5P4 4/20 0.49
HSP90AA1 P07900 3/20 0.49
HTT P42858 3/20 0.49
TLR9 Q9NR96 2/20 0.49
MITF O75030 1/20 0.49
ATM Q13315 1/20 0.49
PKM P14618 2/20 0.47
CCR6 P51684 2/20 0.47
APOBEC3G Q9HC16 2/20 0.47
LMNA P02545 2/20 0.47
HPGD P15428 2/20 0.47
MEN1 O00255 1/20 0.47
G6PD P11413 1/20 0.47
ALOX12 P18054 1/20 0.47
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MAPT P10636 3/20 0.46
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5075617 0.83 MGLL (0.59) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL10587424 0.82 NPSR1 (0.57) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL9152877 0.80 MGLL (0.55) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL30645221 0.80 MGLL (0.58) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL5081392 0.78 MGLL (0.56) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL8155583 0.78 KMT2A (0.62) ALDH1A1NPSR1HPGDMEN1ALOX12
SCHEMBL10704901 0.76 MGLL (0.55) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL11647371 0.76 HSP90AA1 (0.54) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL20945174 0.76 ALDH1A1 (0.58) MGLLALDH1A1NPSR1HSP90AA1HTT
SCHEMBL9154820 0.76 ALDH1A1 (0.63) MGLLALDH1A1NPSR1HSP90AA1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4497928-A Moldable polyblend containing poly(arylene sulfide) ATLANTIC RICHFIELD COMPANY (US) 1985-02-05 US claimed
EP-0303782-B1 Resin Composition SUMITOMO DOW LTD (JP) 1995-01-11 EP disclosed
EP-0267574-B1 HEAT RESISTANT COPOLYMER COMPOSITION Sumitomo Dow Limited (JP) 1993-09-01 EP disclosed
US-4877833-A BLEND OF POLYMERS OF SPECIFIC COMPOSITION SUMITOMO NAUGATUCK CO., LTD. (JP) 1989-10-31 US disclosed
EP-0031997-B2 POLYMERISATION PROCESS FOR PRODUCTION OF POLYMER MICROPARTICLES OF HIGH REFRACTIVE INDEX AND COATING COMPOSITIONS CONTAINING THEM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-09-14 EP disclosed
US-4653584-A Maleimide-modified bioresistant polymers and enhanced oil recovery method employing same THE STANDARD OIL COMPANY (US) 1987-03-31 US disclosed
US-4563209-A ALGAE AND SHELLFISH IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1986-01-07 US disclosed
US-4542187-A MALEIMIDE-VINYL AROMATIC COPOLYMER, HYDROLYTIC STABILITY, MOLDING MATERIALS ATLANTIC RICHFIELD COMPANY (US) 1985-09-17 US disclosed
US-4497928-A Moldable polyblend containing poly(arylene sulfide) ATLANTIC RICHFIELD COMPANY (US) 1985-02-05 US disclosed
US-4427820-A STYRENE, MALEIC ACID DERIVATIVE, EMULSION POLYMERIZATION IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-24 US disclosed
EP-0031997-B1 POLYMERISATION PROCESS FOR PRODUCTION OF POLYMER MICROPARTICLES OF HIGH REFRACTIVE INDEX AND COATING COMPOSITIONS CONTAINING THEM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-12-28 EP disclosed
EP-0031997-A1 Polymerisation process for production of polymer microparticles of high refractive index and coating compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-07-15 EP disclosed
EP-0010107-A1 REPELLENT AGAINST AQUATIC ORGANISMS IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1980-04-30 EP disclosed
US-4111879-A RESIN AND AN N-ARYL-MALEIMIDE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1978-09-05 US disclosed