Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TLR3 | O15455 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938882 | 0.81 | CYP3A4 (0.44) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL27342629 | 0.79 | ALDH1A1 (0.41) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL6935009 | 0.75 | CYP19A1 (0.39) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL10512684 | 0.74 | HSP90AA1 (0.42) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL10512678 | 0.74 | HSP90AA1 (0.42) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL10512674 | 0.74 | HSP90AA1 (0.42) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL6931992 | 0.74 | CYP19A1 (0.40) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL20704108 | 0.73 | PNMT (0.47) | HIF1AALDH1A1CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7655403 | 0.73 | HIF1A (0.47) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL9155877 | 0.72 | TDP1 (0.45) | HIF1AHSP90AA1ALDH1A1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401848-A | Indane and quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0488616-A1 | Indane and quinoline derivatives | E.R. SQUIBB & SONS, INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| EP-0321175-A1 | Indane derivatives | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |