Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180947 | 0.82 | CYP19A1 (0.39) | CYP19A1ALDH1A1CYP3A4PDE2APDE5A | |
| SCHEMBL6936648 | 0.80 | CYP19A1 (0.40) | CYP19A1ALDH1A1LMNA | |
| SCHEMBL6930525 | 0.78 | POLB (0.37) | CYP19A1ALDH1A1PDE4BPDE4DPDE7A | |
| SCHEMBL8172174 | 0.76 | CYP19A1 (0.45) | CYP19A1ALDH1A1CYP3A4PDE2APDE5A | |
| SCHEMBL6935009 | 0.75 | CYP19A1 (0.39) | CYP19A1ALDH1A1CYP3A4ALOX15APEX1 | |
| SCHEMBL6938882 | 0.74 | CYP3A4 (0.44) | ALDH1A1CYP3A4APEX1HSP90AA1HIF1A | |
| SCHEMBL9156355 | 0.74 | HIF1A (0.46) | ALDH1A1HSP90AA1HIF1ALMNACHRNB4 | |
| SCHEMBL6936617 | 0.73 | KCNE1 (0.53) | LMNACA12CA1CA2CA7 | |
| SCHEMBL27342629 | 0.71 | ALDH1A1 (0.41) | ALDH1A1HSP90AA1HIF1ACHRNB4CHRNA3 | |
| SCHEMBL7764313 | 0.70 | PNMT (0.49) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-6015822-A | ANTIULCER, ANTIDIARRHEA, AND ANTIARRHYTHMIA AGENTS; CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-01-18 | — | — | US | disclosed |
| EP-0915087-A2 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-12 | — | — | EP | disclosed |