SCHEMBL9162328

SCHEMBL9162328

O=C1CCN(OCc2ccccc2)C(c2ccccc2)C1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
ALDH1A1 P00352 2/20 0.38
KCNA5 P22460 4/20 0.37
EPHX2 P34913 2/20 0.36
TSHR P16473 2/20 0.35
HPGD P15428 1/20 0.35
CHRM2 P08172 1/20 0.34
CHRM3 P20309 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA7 P36544 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC18A3 Q16572 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21836003 0.79 CHRNB2 (0.40) TSHRCHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL20449099 0.76 PARP1 (0.53) CYP2C19CYP3A4CYP2C9
SCHEMBL3155289 0.76 PARP1 (0.53) CYP2C19CYP3A4CYP2C9
SCHEMBL24365247 0.75 PARP1 (0.46) CYP2C19TSHRHPGDCHRM2CHRM3
SCHEMBL26993918 0.73 NPC1 (0.39) CYP2C9ALDH1A1TSHRSLC18A3
SCHEMBL3119794 0.72 ALDH1A1 (0.46) CYP2C19ALDH1A1KCNA5TSHR
SCHEMBL28064896 0.71 RIPK1 (0.48) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL3657493 0.70 CYP2C19 (0.46) CYP2C19CYP3A4CYP2C9ALDH1A1HPGD
SCHEMBL360290 0.69 GAA (0.41) ALDH1A1TSHRCHRNB2CHRNB4CHRNA3
SCHEMBL20449106 0.69 PARP1 (0.48) CYP2C19CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0305180-B1 Enantioselective reduction of ketones HARVARD COLLEGE (US) 1995-03-22 EP disclosed
US-4943635-A OXAZABOROLIDINES AND OXAZABORINES AS CATALYSTS PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) 1990-07-24 US disclosed
EP-0305180-A2 Enantioselective reduction of ketones THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1989-03-01 EP disclosed