Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10382845 | 0.93 | ALDH1A1 (0.41) | ALDH1A1POLBTSHRKMT2APKM | |
| SCHEMBL2982806 | 0.80 | TSHR (0.46) | ALDH1A1TSHRNPC1RAB9AIDO1 | |
| SCHEMBL15094370 | 0.80 | TSHR (0.46) | ALDH1A1TSHRIDO1 | |
| SCHEMBL9744353 | 0.79 | SIGMAR1 (0.47) | TSHRNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2978407 | 0.79 | LMNA (0.46) | ALDH1A1TSHRNPC1RAB9AIDO1 | |
| SCHEMBL447549 | 0.79 | SIGMAR1 (0.47) | TSHRNPC1RAB9A | |
| SCHEMBL2917851 | 0.77 | L3MBTL1 (0.46) | ALDH1A1POLBKMT2APKML3MBTL1 | |
| Bromide SCHEMBL28805308 | 0.77 | SIGMAR1 (0.46) | TSHRNPC1RAB9A | |
| SCHEMBL27166512 | 0.76 | LMNA (0.47) | ALDH1A1TSHRKMT2ACYP2C19MEN1 | |
| SCHEMBL28598923 | 0.76 | TSHR (0.50) | ALDH1A1TSHRIDO1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916552-B2 | Pharmaceutical combinations | ASTEX THERAPEUTICS LIMITED (GB) | 2014-12-23 | — | — | US | disclosed |
| US-8362255-B2 | Process for the manufacture of [phenylsulfanylphenyl]piperidines | H. LUNDBECK A/S (DK) | 2013-01-29 | — | — | US | disclosed |
| EP-2260024-B1 | PROCESS FOR THE MANUFACTURE OF [PHENYLSULFANYLPHENYL] PIPERIDINES | LUNDBECK & CO AS H (DK) | 2011-12-28 | — | — | EP | disclosed |
| US-20110054178-A1 | PROCESS FOR THE MANUFACTURE OF [PHENYLSULFANYLPHENYL]PIPERIDINES | H. LUNDBECK A/S (DK) | 2011-03-03 | — | — | US | disclosed |
| US-20100179145-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054178-A1 | PROCESS FOR THE MANUFACTURE OF [PHENYLSULFANYLPHENYL]PIPERIDINES | NPEPPS, UMPS, DHPS | ALDH1A1 575/4885POLB 939/4885TSHR 3708/4885 |
| US-20100179145-A1 | PHARMACEUTICAL COMBINATIONS | GSK3B, CDK1, CDK6 | ALDH1A1 3443/4885POLB 2362/4885TSHR 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.