Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417656 | 0.82 | NAAA (0.54) | KMT2AALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL9170924 | 0.80 | CETP (0.45) | KMT2AL3MBTL1CNR2ALDH1A1HPGD | |
| SCHEMBL9172738 | 0.80 | PLA2G2A (0.53) | — | |
| SCHEMBL9165252 | 0.78 | TSHR (0.51) | L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL10789494 | 0.77 | ALDH1A1 (0.48) | KMT2AL3MBTL1CNR2ALDH1A1HPGD | |
| SCHEMBL9168493 | 0.75 | PLA2G2A (0.44) | KMT2AL3MBTL1ALDH1A1HDAC6 | |
| SCHEMBL10724585 | 0.75 | HPGD (0.61) | ALDH1A1HPGD | |
| SCHEMBL9163857 | 0.75 | PLA2G2A (0.65) | L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL9016911 | 0.74 | ALDH1A1 (0.55) | ALDH1A1HPGD | |
| SCHEMBL28678550 | 0.74 | ALDH1A1 (0.50) | KMT2AL3MBTL1CNR2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |