Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 8/20 | 0.35 |
| ▸ | MAOB | P27338 | 8/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193087 | 0.79 | ALOX15 (0.42) | MAPTGAAL3MBTL1TDP1RAB9A | |
| SCHEMBL10880606 | 0.77 | GAA (0.40) | MAPTGAATSHRMAPK1 | |
| SCHEMBL6098708 | 0.75 | MAPT (0.48) | MAPTGAALMNAL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL28604267 | 0.74 | GAA (0.44) | MAPTGAAMAOAMAOBTSHR | |
| SCHEMBL10345713 | 0.69 | MAPT (0.41) | MAPTGAALMNACYP1A2CYP2C19 | |
| SCHEMBL28658376 | 0.69 | MAPT (0.41) | MAPTGAALMNATSHRMAPK1 | |
| SCHEMBL27552412 | 0.68 | MAPT (0.40) | MAPTGAARAB9ASMN1; SMN2 | |
| SCHEMBL28592964 | 0.66 | MAPT (0.35) | MAPTGAARAB9ASMN1; SMN2 | |
| SCHEMBL3732226 | 0.66 | GAA (0.50) | MAPTGAALMNASMN1; SMN2 | |
| SCHEMBL7414784 | 0.65 | MAPT (0.54) | MAPTGAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970125-B1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2018-07-18 | — | — | EP | disclosed |
| US-9956213-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2018-05-01 | — | — | US | disclosed |
| US-20170312263-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2017-11-02 | — | — | US | disclosed |
| US-20170273968-A1 | MAO-B INHIBITORS AND REHABILITATION | DART NEUROSCIENCE, LLC | 2017-09-28 | — | — | US | disclosed |
| CN-107073296-A | MAO B inhibitor and rehabilitation | 达特神经科学(开曼)有限公司 | 2017-08-18 | — | — | CN | disclosed |
| EP-3194026-A1 | MAO-B INHIBITORS AND REHABILITATION | Dart NeuroScience (Cayman) Ltd. (KY) | 2017-07-26 | — | — | EP | disclosed |
| US-9675605-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2017-06-13 | — | — | US | disclosed |
| WO-2016044635-A1 | MAO-B INHIBITORS AND REHABILITATION | DART NEUROSCIENCE, LLC (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20160074377-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE, LLC | 2016-03-17 | — | — | US | disclosed |
| EP-2970125-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | Dart Neuroscience (Cayman) Ltd (KY) | 2016-01-20 | — | — | EP | disclosed |
| US-9150572-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-10-06 | — | — | US | disclosed |
| US-9102674-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-08-11 | — | — | US | disclosed |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2014-10-23 | — | — | US | disclosed |
| WO-2014158916-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE, LLC (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140275548-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2014-09-18 | — | — | US | disclosed |
| EP-0380355-B1 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4861771-A | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160074377-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | MAPT 873/4885GAA 57/4885TNKS2 1828/4885 |
| US-20170312263-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | MAPT 888/4885GAA 59/4885TNKS2 1918/4885 |
| US-20140275548-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | MAPT 873/4885GAA 57/4885TNKS2 1828/4885 |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | MAPT 888/4885GAA 59/4885TNKS2 1918/4885 |
| US-20170273968-A1 | MAO-B INHIBITORS AND REHABILITATION | MAOB, MAOA, HTR2B | MAPT 807/4885GAA 157/4885TNKS2 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.