Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9169239 | 0.82 | PIM1 (0.55) | PIM1SMN1; SMN2KDM4ERAB9ANOTUM | |
| SCHEMBL28636871 | 0.76 | PIM1 (0.50) | PIM1SMN1; SMN2NOTUMIKBKBMAPK14 | |
| SCHEMBL9169037 | 0.75 | ALDH1A1 (0.58) | KDM4EGRIN1GRIN2BMAPTCYP1A2 | |
| SCHEMBL9163642 | 0.73 | NPSR1 (0.56) | KDM4EGRIN1GRIN2BMAPTKDM5B | |
| SCHEMBL9166887 | 0.73 | NPSR1 (0.55) | SMN1; SMN2KDM4ERAB9AGRIN2BMAPT | |
| SCHEMBL11624173 | 0.72 | MAPK14 (0.62) | PIM1SMN1; SMN2NOTUMIKBKBMAPK14 | |
| SCHEMBL28657289 | 0.72 | PIM1 (0.44) | PIM1SMN1; SMN2KDM4ENOTUMIKBKB | |
| SCHEMBL10429345 | 0.69 | TDO2 (0.51) | PIM1NOTUMMAPK14SCN2AMAPK11 | |
| SCHEMBL2556657 | 0.69 | MGLL (0.47) | KDM4EGRIN1GRIN2BIKBKBIDO1 | |
| SCHEMBL31014304 | 0.68 | ATM (0.61) | SMN1; SMN2KDM4ERAB9ATRPA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555957-A1 | Pyrido 2,3-d pyridazine derivatives as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-08-18 | — | — | EP | claimed |
| US-5405826-A | Herbicidal pyridopyridazinones and pyridopyridazinethiones | RHONE POULENC AGRICULTURE LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0555957-A1 | Pyrido 2,3-d pyridazine derivatives as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-08-18 | — | — | EP | disclosed |