Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | OGT | O15294 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170969 | 0.79 | ALDH1A1 (0.59) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL9169224 | 0.79 | HTR1A (0.47) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL9170956 | 0.75 | HTR1A (0.45) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL9249330 | 0.72 | CRBN (0.41) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL9170241 | 0.72 | ALDH1A1 (0.46) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL9170234 | 0.72 | ALDH1A1 (0.46) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL10464326 | 0.69 | GRIN2B (0.60) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL23196645 | 0.68 | ALPG (0.47) | — | |
| SCHEMBL10837493 | 0.68 | HTR1A (0.65) | HTR1ADRD4HTR2AHTR7DRD3 | |
| SCHEMBL8499767 | 0.68 | MAOA (0.47) | HTR1ADRD4HTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434164-A | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0240015-B1 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5008274-A | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0240015-A2 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-07 | — | — | EP | disclosed |