SCHEMBL917356

SCHEMBL917356

CCc1ccc(Nc2ccc([Si](C)(C)C)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.49
NPC1 O15118 2/20 0.49
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
IL6 P05231 1/20 0.42
STAT3 P40763 1/20 0.42
CXCR4 P61073 1/20 0.42
HPGD P15428 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
TUBA1B P68363 1/20 0.40
TUBA4A P68366 1/20 0.40
TUBB4B P68371 1/20 0.40
TUBB3 Q13509 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8306401 0.87 TP53 (0.46) CYP1A2ALDH1A1MAPK1L3MBTL1
SCHEMBL916738 0.86 NPC1 (0.41) RAB9ANPC1MEN1KMT2AIL6
SCHEMBL2270398 0.84 ALDH1A1 (0.43) RAB9ANPC1MEN1KMT2AHPGD
SCHEMBL49571 0.84 RAB9A (0.55) RAB9ANPC1MEN1KMT2ACXCR4
SCHEMBL19743210 0.80 NOTUM (0.43) RAB9ANPC1CYP1A2ALDH1A1POLB
SCHEMBL13769425 0.78 UCHL1 (0.55) RAB9ANPC1MEN1KMT2ACXCR4
SCHEMBL9418580 0.78 RAB9A (0.50) RAB9ANPC1MEN1KMT2ACXCR4
SCHEMBL11478969 0.77 RAB9A (0.65) RAB9ANPC1MEN1KMT2ACXCR4
SCHEMBL22228586 0.76 HPGD (0.56) RAB9ANPC1MEN1KMT2AHPGD
SCHEMBL2749762 0.76 ALDH1A1 (0.62) RAB9ANPC1MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8647754-B2 Aromatic diamine derivative and organic electroluminescent device using the same IDEMITSU KOSAN CO., LTD. (JP) 2014-02-11 US disclosed
US-20110006289-A1 AROMATIC DIAMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2011-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110006289-A1 AROMATIC DIAMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME AOC1, DDC, CCNL2 RAB9A 1560/4885NPC1 4009/4885MEN1 1230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.