Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174736 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SLC18A3HSD17B10GAA | |
| SCHEMBL8576377 | 0.81 | KDM4E (0.40) | ALDH1A1KMT2A | |
| SCHEMBL9303669 | 0.80 | CA2 (0.35) | ALDH1A1POLBHSD17B10GAAKMT2A | |
| SCHEMBL9175683 | 0.79 | RAB9A (0.34) | ALDH1A1KMT2APTGS2LMNA | |
| SCHEMBL9172583 | 0.78 | PARP1 (0.43) | HSD17B10KMT2AMEN1 | |
| SCHEMBL8574206 | 0.76 | HPGD (0.46) | ALDH1A1TDP1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL8796640 | 0.75 | RAB9A (0.44) | ALDH1A1POLBSMN1; SMN2HPGDLMNA | |
| SCHEMBL8576526 | 0.75 | SMN1; SMN2 (0.33) | GAASMN1; SMN2HPGD | |
| SCHEMBL8638816 | 0.73 | ALDH1A1 (0.41) | ALDH1A1SLC18A3GAAELANEPTGS2 | |
| SCHEMBL10495293 | 0.71 | SMN1; SMN2 (0.67) | ALDH1A1POLBAPEX1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |